Overproduction of the pro-apoptotic molecule, programmed cell death 5, in Toxoplasma gondii leads to increased apoptosis of host macrophages

We established a recombinant strain of Toxoplasma gondii that overexpressed programmed cell death 5 (TgPDCD5), in order to evaluate the role of endogenous TgPDCD5 in macrophage apoptosis during T. gondii infection. Immunofluorescence microscopy revealed that overproduced TgPDCD5 with a hemagglutinin...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2009, Vol.71(9), pp.1183-1189
Hauptverfasser:	Bannai, H.(Obihiro Univ. of Agriculture and Veterinary Medicine, Hokkaido (Japan)), Nishikawa, Y, Ibrahim, H.M, Yamada, K, Kawase, O, Watanabe, J, Sugimoto, C, Xuan, X
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL ANIMALES ANIMALS APOPTOSE APOPTOSIS Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism BIOLOGIA MOLECULAR BIOLOGIE MOLECULAIRE Cell Line Cercopithecus aethiops CHO Cells Cricetinae Cricetulus Gene Expression Regulation - physiology MACROFAGOS MACROPHAGE MACROPHAGES Macrophages - physiology MOLECULAR BIOLOGY overexpression PDCD5 RECOMBINACION RECOMBINAISON RECOMBINATION Toxoplasma - metabolism TOXOPLASMA GONDII Vero Cells
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