Immunization with a DNA chimeric molecule encoding a hemagglutinin peptide and a scFv CD21-specific antibody fragment induces long-lasting IgM and CTL responses to influenza virus

Killed viral vaccines are known to induce primarily antibody responses. By contrast DNA vaccination using naked DNA encoding viral antigens induces both humoral and cellular immune responses. Various approaches have been used to construct DNA vaccines with build-in adjuvanticity. We hypothesized tha...

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Veröffentlicht in:	Vaccine 2006-03, Vol.24 (11), p.1830-1837
Hauptverfasser:	Ivanovska, Nina, Tchorbanov, Andrey, Prechl, Jozsef, Maximova, Vera, Voynova, Elisaveta, Vassilev, Tchavdar L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antibodies, Viral - blood Antigens Applied microbiology Biological and medical sciences CTL response Cytokines Cytotoxicity Cytotoxicity, Immunologic Deoxyribonucleic acid DNA DNA vaccines Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Immune system Immunization Immunogenicity Immunoglobulin G - blood Immunoglobulin M - blood Immunoglobulin Variable Region - genetics Influenza A virus Influenza A virus - immunology Influenza Vaccines - immunology Influenza virus Mice Mice, Inbred BALB C Microbiology Miscellaneous Peptides Plasmids Proteins Receptors, Complement - immunology Receptors, Complement 3d - immunology Rodents T-Lymphocytes, Cytotoxic - immunology Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Virology
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