Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

Glial cell line-derived neurotrophic factor (GDNF) has been shown to increase the survival and functioning of dopamine neurons in a variety of animal models and some recent human trials. However, delivery of any protein to the brain remains a challenge due to the blood/brain barrier. Here we show th...

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Veröffentlicht in:	Gene therapy 2006-03, Vol.13 (5), p.379-388
Hauptverfasser:	Behrstock, S, Ebert, A, McHugh, J, Vosberg, S, Moore, J, Schneider, B, Capowski, E, Hei, D, Kordower, J, Aebischer, P, Svendsen, C N
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Animals Applied cell therapy and gene therapy Basal ganglia Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Blood-brain barrier Blotting, Western - methods Brain - metabolism Brain tumors Care and treatment Cell Biology Central nervous system Central nervous system diseases Dopamine Dopamine - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor - analysis Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - secretion Glial cells Glial stem cells Growth factors Haplorhini Health aspects Health. Pharmaceutical industry Hemopoiesis Human Genetics Humans Immunohistochemistry - methods Industrial applications and implications. Economical aspects Lentivirus - genetics Medical sciences Movement disorders Nanotechnology Neostriatum Nervous system Neural stem cells Neurodegenerative diseases Neuronal-glial interactions Neurons Neurons - metabolism Neurons - physiology original-article Parkinson's disease Parkinsonian Disorders - therapy Primates Progenitor cells Rats Rats, Sprague-Dawley Stem Cell Transplantation - methods Stem cells Stem Cells - physiology Substantia nigra Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation
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