CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs

We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This localization requires the RdRP EGO-1, which physically interacts with CDE-1, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2009-10, Vol.139 (1), p.135-148
Hauptverfasser:	van Wolfswinkel, Josien C., Claycomb, Julie M., Batista, Pedro J., Mello, Craig C., Berezikov, Eugene, Ketting, René F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - analysis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Cycle Proteins - analysis Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism CELLCYCLE Chromosome Segregation Meiosis Metaphase Mitosis RNA RNA Interference RNA Replicase - metabolism RNA, Small Interfering - metabolism Uridine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!