Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin

Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to the extracellular domains of human (hu) and mouse TLR5. Adjuvancy of rtTLR5S to flagellin response by human TLR5 (huTLR5) was...

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Veröffentlicht in:	Vaccine 2006-03, Vol.24 (12), p.2193-2199
Hauptverfasser:	Tsujita, Tadayuki, Ishii, Akihiro, Tsukada, Hironobu, Matsumoto, Misako, Che, Fang-Sik, Seya, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Amino Acid Sequence Animals Applied microbiology Bacterial flagellin Bacteriology Biological and medical sciences Cloning Fish Flagellin - isolation & purification Flagellin - metabolism Fundamental and applied biological sciences. Psychology Genes HeLa Cells Humans Mammals Microbiology Miscellaneous Molecular Sequence Data Oncorhynchus mykiss Proteins Toll-Like Receptor 5 - chemistry Toll-Like Receptor 5 - genetics Toll-Like Receptor 5 - metabolism Toll-like receptors Trout Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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