The effects of vehicle and region of application on in vitro penetration of testosterone through canine skin

The effects of the vehicles phosphate-buffered saline (PBS), ethanol (EtOH; 50% in PBS w/w) and propylene glycol (PG; 50% in PBS w/w) and the region of administration on in vitro transdermal penetration of testosterone was investigated in the dog. Skin was harvested from the thorax, neck (dorsal par...

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Veröffentlicht in:	The veterinary journal (1997) 2006-03, Vol.171 (2), p.276-280
Hauptverfasser:	Mills, Paul C., Magnusson, Beatrice M., Cross, Sheree E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous adsorption Animals buffers dog diseases Dog Diseases - drug therapy Dog Diseases - metabolism Dogs drug delivery systems drug evaluation drug formulations ethanol Ethanol - pharmacology Greyhound dogs In Vitro Techniques limbs (animal) Male neck Permeability phosphates polyethylene glycol Propylene Glycol - pharmacology Skin Skin - metabolism Skin Absorption - physiology Solvents - pharmacology Testosterone Testosterone - administration & dosage Testosterone - pharmacokinetics thorax Topical topical application Transdermal transdermal application urinary incontinence urinary tract diseases urination
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