Ageing-related chromatin defects through loss of the NURD complex

Cells undergoing normal or premature ageing show several global defects in chromatin. Components of the NURD chromatin remodelling complex, such as histone chaperones, are now shown to be lost in cells from patients with a premature aging disorder and in normally aged cells. Conversely, depleting NU...

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Veröffentlicht in:	Nature cell biology 2009-10, Vol.11 (10), p.1261-1267
Hauptverfasser:	Pegoraro, Gianluca, Kubben, Nard, Wickert, Ute, Göhler, Heike, Hoffmann, Katrin, Misteli, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Accumulation Aged, 80 and over Aging Aging - genetics Amino Acid Sequence Amino acids Biomedical and Life Sciences Cancer Research Causes of Cell Biology Cells, Cultured Child Chromatin Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Deoxyribonucleic acid Dermis - cytology Developmental Biology DNA DNA Damage DNA Methylation Fibroblasts - cytology Fibroblasts - metabolism HeLa Cells Histone Deacetylase 1 Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans letter Life Sciences Medical research Mi-2 Nucleosome Remodeling and Deacetylase Complex Molecular Sequence Data Mutation Nucleosomes Physiological aspects Physiology Protein Subunits - metabolism Proteins RNA, Small Interfering - pharmacology Stem Cells Transfection Two-Hybrid System Techniques Yeast
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