The Ventilatory Stimulant Doxapram Inhibits TASK Tandem Pore (K2P) Potassium Channel Function but Does Not Affect Minimum Alveolar Anesthetic Concentration

TWIK-related acid-sensitive K+-1 (TASK-1 [KCNK3]) and TASK-3 (KCNK9) are tandem pore (K2P) potassium (K) channel subunits expressed in carotid bodies and the brainstem. Acidic pH values and hypoxia inhibit TASK-1 and TASK-3 channel function, and halothane enhances this function. These channels have...

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Veröffentlicht in:	Anesthesia and analgesia 2006-03, Vol.102 (3), p.779-785
Hauptverfasser:	Cotten, Joseph F., Keshavaprasad, Bharat, Laster, Michael J., Eger, Edmond I., Yost, C Spencer
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - metabolism Anesthetics, Inhalation - pharmacology Animals Biological and medical sciences Central Nervous System Stimulants - metabolism Central Nervous System Stimulants - pharmacology Dose-Response Relationship, Drug Doxapram - metabolism Doxapram - pharmacology Female Humans Male Medical sciences Mice Potassium Channels, Tandem Pore Domain - antagonists & inhibitors Potassium Channels, Tandem Pore Domain - physiology Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Ventilation - drug effects Pulmonary Ventilation - physiology Rats Rats, Sprague-Dawley Respiratory System Agents - metabolism Respiratory System Agents - pharmacology Xenopus laevis
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