Moderate effect of enamel matrix derivative (Emdogain ® Gel) on Porphyromonas gingivalis growth in vitro
The aim of this study was to analyse the antibacterial effects of Emdogain ® Gel or its constituents on the growth of the suspected periodontopathogen Porphyromonas gingivalis. The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain ® Gel or its vehicle propyle...
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| Veröffentlicht in: | Archives of oral biology 2006-03, Vol.51 (3), p.171-176 |
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| creator | Walter, Clemens Jawor, Przemyslaw Bernimoulin, Jean-Pierre Hägewald, Stefan |
| description | The aim of this study was to analyse the antibacterial effects of Emdogain
® Gel or its constituents on the growth of the suspected periodontopathogen
Porphyromonas gingivalis.
The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain
® Gel or its vehicle propylene glycol alginate (PGA) (Straumann, Switzerland) on
P. gingivalis growth were determined by two methods: broth dilution assay (BDA) and agar diffusion assay (ADA).
BDA—Emdogain
® Gel inhibited moderately the growth of
P. gingivalis, whereas EMD showed no effect. The PGA vehicle inhibited the growth completely. ADA—Emdogain
® Gel resulted in some inhibition in growth but was not significantly different from control. EMD revealed no zone of inhibition. PGA demonstrated statistically significant zones of inhibition.
Emdogain
® Gel shows moderate antibacterial activities against
P. gingivalis. These properties seem to be due to the PGA component of the gel preparation. |
| doi_str_mv | 10.1016/j.archoralbio.2005.07.005 |
| format | Article |
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® Gel or its constituents on the growth of the suspected periodontopathogen
Porphyromonas gingivalis.
The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain
® Gel or its vehicle propylene glycol alginate (PGA) (Straumann, Switzerland) on
P. gingivalis growth were determined by two methods: broth dilution assay (BDA) and agar diffusion assay (ADA).
BDA—Emdogain
® Gel inhibited moderately the growth of
P. gingivalis, whereas EMD showed no effect. The PGA vehicle inhibited the growth completely. ADA—Emdogain
® Gel resulted in some inhibition in growth but was not significantly different from control. EMD revealed no zone of inhibition. PGA demonstrated statistically significant zones of inhibition.
Emdogain
® Gel shows moderate antibacterial activities against
P. gingivalis. These properties seem to be due to the PGA component of the gel preparation.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2005.07.005</identifier><identifier>PMID: 16137640</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alginates - pharmacology ; Anti-Bacterial Agents - pharmacology ; Antibacterial effects ; Colony Count, Microbial - methods ; Dental Enamel Proteins - pharmacology ; Dentistry ; Drug Evaluation, Preclinical ; Enamel matrix derivative ; Immunosorbents - pharmacology ; Porphyromonas gingivalis ; Porphyromonas gingivalis - drug effects ; Porphyromonas gingivalis - growth & development ; Virulence</subject><ispartof>Archives of oral biology, 2006-03, Vol.51 (3), p.171-176</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c290t-10fad8d0c4efa556483c2c55fdefa142165ef9a7eff1df8788eb49e75d37be3b3</citedby><cites>FETCH-LOGICAL-c290t-10fad8d0c4efa556483c2c55fdefa142165ef9a7eff1df8788eb49e75d37be3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2005.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16137640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walter, Clemens</creatorcontrib><creatorcontrib>Jawor, Przemyslaw</creatorcontrib><creatorcontrib>Bernimoulin, Jean-Pierre</creatorcontrib><creatorcontrib>Hägewald, Stefan</creatorcontrib><title>Moderate effect of enamel matrix derivative (Emdogain ® Gel) on Porphyromonas gingivalis growth in vitro</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>The aim of this study was to analyse the antibacterial effects of Emdogain
® Gel or its constituents on the growth of the suspected periodontopathogen
Porphyromonas gingivalis.
The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain
® Gel or its vehicle propylene glycol alginate (PGA) (Straumann, Switzerland) on
P. gingivalis growth were determined by two methods: broth dilution assay (BDA) and agar diffusion assay (ADA).
BDA—Emdogain
® Gel inhibited moderately the growth of
P. gingivalis, whereas EMD showed no effect. The PGA vehicle inhibited the growth completely. ADA—Emdogain
® Gel resulted in some inhibition in growth but was not significantly different from control. EMD revealed no zone of inhibition. PGA demonstrated statistically significant zones of inhibition.
Emdogain
® Gel shows moderate antibacterial activities against
P. gingivalis. These properties seem to be due to the PGA component of the gel preparation.</description><subject>Alginates - pharmacology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial effects</subject><subject>Colony Count, Microbial - methods</subject><subject>Dental Enamel Proteins - pharmacology</subject><subject>Dentistry</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enamel matrix derivative</subject><subject>Immunosorbents - pharmacology</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - drug effects</subject><subject>Porphyromonas gingivalis - growth & development</subject><subject>Virulence</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOxCAUhonR6Hh5BYMbo4tWmBZol2biLdHoQteEwmGGSVtG6Iz6Uj6ETyZmJtGlq58TvsM5fAidUJJTQvnFPFdBz3xQbeN8PiaE5UTkKbbQiFaizigjfBuNCCFFVte83kP7Mc5TyTinu2iPcloIXpIRcg_eQFADYLAW9IC9xdCrDlrcqSG4d5yu3UoNbgX47Kozfqpcj78-8Q2059j3-MmHxewj-M73KuKp66cJb106Bv82zHCiV24I_hDtWNVGONrkAXq5vnqe3Gb3jzd3k8v7TI9rMmSUWGUqQ3QJVjHGy6rQY82YNamm5ZhyBrZWIq1Lja1EVUFT1iCYKUQDRVMcoNP1u4vgX5cQB9m5qKFtVQ9-GSUXXAjGigTWa1AHH2MAKxfBdSp8SErkj2c5l388yx_PkgiZIvUeb4Ysmw7Mb-dGbAImawDSV1cOgozaQa_BuJA0S-PdP8Z8A6Nel-M</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Walter, Clemens</creator><creator>Jawor, Przemyslaw</creator><creator>Bernimoulin, Jean-Pierre</creator><creator>Hägewald, Stefan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Moderate effect of enamel matrix derivative (Emdogain ® Gel) on Porphyromonas gingivalis growth in vitro</title><author>Walter, Clemens ; Jawor, Przemyslaw ; Bernimoulin, Jean-Pierre ; Hägewald, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-10fad8d0c4efa556483c2c55fdefa142165ef9a7eff1df8788eb49e75d37be3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alginates - pharmacology</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial effects</topic><topic>Colony Count, Microbial - methods</topic><topic>Dental Enamel Proteins - pharmacology</topic><topic>Dentistry</topic><topic>Drug Evaluation, Preclinical</topic><topic>Enamel matrix derivative</topic><topic>Immunosorbents - pharmacology</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - drug effects</topic><topic>Porphyromonas gingivalis - growth & development</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walter, Clemens</creatorcontrib><creatorcontrib>Jawor, Przemyslaw</creatorcontrib><creatorcontrib>Bernimoulin, Jean-Pierre</creatorcontrib><creatorcontrib>Hägewald, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walter, Clemens</au><au>Jawor, Przemyslaw</au><au>Bernimoulin, Jean-Pierre</au><au>Hägewald, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate effect of enamel matrix derivative (Emdogain ® Gel) on Porphyromonas gingivalis growth in vitro</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>51</volume><issue>3</issue><spage>171</spage><epage>176</epage><pages>171-176</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>The aim of this study was to analyse the antibacterial effects of Emdogain
® Gel or its constituents on the growth of the suspected periodontopathogen
Porphyromonas gingivalis.
The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain
® Gel or its vehicle propylene glycol alginate (PGA) (Straumann, Switzerland) on
P. gingivalis growth were determined by two methods: broth dilution assay (BDA) and agar diffusion assay (ADA).
BDA—Emdogain
® Gel inhibited moderately the growth of
P. gingivalis, whereas EMD showed no effect. The PGA vehicle inhibited the growth completely. ADA—Emdogain
® Gel resulted in some inhibition in growth but was not significantly different from control. EMD revealed no zone of inhibition. PGA demonstrated statistically significant zones of inhibition.
Emdogain
® Gel shows moderate antibacterial activities against
P. gingivalis. These properties seem to be due to the PGA component of the gel preparation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16137640</pmid><doi>10.1016/j.archoralbio.2005.07.005</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9969 |
| ispartof | Archives of oral biology, 2006-03, Vol.51 (3), p.171-176 |
| issn | 0003-9969 1879-1506 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alginates - pharmacology Anti-Bacterial Agents - pharmacology Antibacterial effects Colony Count, Microbial - methods Dental Enamel Proteins - pharmacology Dentistry Drug Evaluation, Preclinical Enamel matrix derivative Immunosorbents - pharmacology Porphyromonas gingivalis Porphyromonas gingivalis - drug effects Porphyromonas gingivalis - growth & development Virulence |
| title | Moderate effect of enamel matrix derivative (Emdogain ® Gel) on Porphyromonas gingivalis growth in vitro |
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