Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling
Leptin, a hormone secreted by adipocytes, acts on the hypothalamus to regulate appetite and neuroendocrine function. In the hypothalamus, both the arcuate nucleus and the ventromedial nucleus express leptin receptors. Specific neurons in the arcuate nucleus regulate appetite and reproduction. In con...
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| Veröffentlicht in: | American journal of medical genetics. Part A 2006-03, Vol.140A (5), p.515-524 |
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| container_title | American journal of medical genetics. Part A |
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| creator | Cohen Jr, M. Michael |
| description | Leptin, a hormone secreted by adipocytes, acts on the hypothalamus to regulate appetite and neuroendocrine function. In the hypothalamus, both the arcuate nucleus and the ventromedial nucleus express leptin receptors. Specific neurons in the arcuate nucleus regulate appetite and reproduction. In contrast, neurons in the ventromedial nucleus regulate bone mass. The melanocortin system is the downstream pathway for regulating appetite and neuroendocrine function. In contrast, the sympathetic nervous system is the downstream pathway for regulating bone mass. Leptin, in regulating food intake and body weight, acts, in part, by inhibiting the synthesis of neuropeptide Y and its release from the hypothalamus. The leptin and insulin pathways may interact and may be important in the pathogenesis of the metabolic syndrome. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.a.31099 |
| format | Article |
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Michael</creator><creatorcontrib>Cohen Jr, M. Michael</creatorcontrib><description>Leptin, a hormone secreted by adipocytes, acts on the hypothalamus to regulate appetite and neuroendocrine function. In the hypothalamus, both the arcuate nucleus and the ventromedial nucleus express leptin receptors. Specific neurons in the arcuate nucleus regulate appetite and reproduction. In contrast, neurons in the ventromedial nucleus regulate bone mass. The melanocortin system is the downstream pathway for regulating appetite and neuroendocrine function. In contrast, the sympathetic nervous system is the downstream pathway for regulating bone mass. Leptin, in regulating food intake and body weight, acts, in part, by inhibiting the synthesis of neuropeptide Y and its release from the hypothalamus. The leptin and insulin pathways may interact and may be important in the pathogenesis of the metabolic syndrome. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4825</identifier><identifier>EISSN: 1552-4833</identifier><identifier>DOI: 10.1002/ajmg.a.31099</identifier><identifier>PMID: 16463275</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>adipokine ; amenorrhea ; Animals ; anorexia nervosa ; Appetite - physiology ; arcuate nucleus ; Biological and medical sciences ; Bone Remodeling - physiology ; Cell Differentiation - physiology ; cocaine amphetamine regulated transcript (CART) ; Female genital diseases ; glucose homeostasis ; Gynecology. Andrology. Obstetrics ; Humans ; hypothalamus ; Hypothalamus - physiology ; insulin signaling ; Leptin - physiology ; Medical sciences ; melanocortin system ; Metabolic diseases ; Models, Biological ; neuropeptide Y ; Neurosecretory Systems - physiology ; Non tumoral diseases ; obese gene (OB) ; Obesity ; Osteoclasts - cytology ; receptor for activated NFκB ligand (RANK) ; Receptors, Cell Surface - physiology ; Receptors, Leptin ; reproductive axis ; sympathetic nervous system ; ventromedial nucleus ; β2 adrenergic receptor (β2-AR)</subject><ispartof>American journal of medical genetics. 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Michael</creatorcontrib><title>Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling</title><title>American journal of medical genetics. Part A</title><addtitle>Am. J. Med. Genet</addtitle><description>Leptin, a hormone secreted by adipocytes, acts on the hypothalamus to regulate appetite and neuroendocrine function. In the hypothalamus, both the arcuate nucleus and the ventromedial nucleus express leptin receptors. Specific neurons in the arcuate nucleus regulate appetite and reproduction. In contrast, neurons in the ventromedial nucleus regulate bone mass. The melanocortin system is the downstream pathway for regulating appetite and neuroendocrine function. In contrast, the sympathetic nervous system is the downstream pathway for regulating bone mass. Leptin, in regulating food intake and body weight, acts, in part, by inhibiting the synthesis of neuropeptide Y and its release from the hypothalamus. The leptin and insulin pathways may interact and may be important in the pathogenesis of the metabolic syndrome. © 2006 Wiley‐Liss, Inc.</description><subject>adipokine</subject><subject>amenorrhea</subject><subject>Animals</subject><subject>anorexia nervosa</subject><subject>Appetite - physiology</subject><subject>arcuate nucleus</subject><subject>Biological and medical sciences</subject><subject>Bone Remodeling - physiology</subject><subject>Cell Differentiation - physiology</subject><subject>cocaine amphetamine regulated transcript (CART)</subject><subject>Female genital diseases</subject><subject>glucose homeostasis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>hypothalamus</subject><subject>Hypothalamus - physiology</subject><subject>insulin signaling</subject><subject>Leptin - physiology</subject><subject>Medical sciences</subject><subject>melanocortin system</subject><subject>Metabolic diseases</subject><subject>Models, Biological</subject><subject>neuropeptide Y</subject><subject>Neurosecretory Systems - physiology</subject><subject>Non tumoral diseases</subject><subject>obese gene (OB)</subject><subject>Obesity</subject><subject>Osteoclasts - cytology</subject><subject>receptor for activated NFκB ligand (RANK)</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Receptors, Leptin</subject><subject>reproductive axis</subject><subject>sympathetic nervous system</subject><subject>ventromedial nucleus</subject><subject>β2 adrenergic receptor (β2-AR)</subject><issn>1552-4825</issn><issn>1552-4833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctv1DAQB2ALgWgp3DijXOC0Wew4tuNjtcAuqDzEQxytiTNZuSR2sBNB_3tcdmlvVLLkh76Zkfwj5Cmja0Zp9RIux_0a1pxRre-RUyZEVdYN5_dvzpU4IY9SuqSUU6HkQ3LCZC15pcQp-fI5DFiEvhhwmp0v8oq4XwbIl30B04Szm3FVeFxiQN8FG53Hol-8nV3wqwJ8V7QhP0UcQ4dDLntMHvQwJHxy3M_Itzevv2525cXH7dvN-UVp83RdKi4o09BIi7StRcU1aLRSWNU2QglopbUgW16DVrzuGKt72na6bkCC6LuGn5EXh75TDD8XTLMZXbI4DOAxLMlIJZVi7G5YUV0JKvidkGlVUVnTDFcHaGNIKWJvpuhGiFeGUXMdi7mOxYD5G0vmz459l3bE7hYfc8jg-RFAsjD0Ebx16dYpoZSqVHb84H65Aa_-O9Scv3u__Te-PFS5NOPvmyqIP_IfcSXM9w9bw3avNrtPTWMk_wOoQbSD</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Cohen Jr, M. Michael</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling</title><author>Cohen Jr, M. Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4639-735019a86ce0b45239a9ec65c7b8575ab6cca6b34a9734d114f0bd948a6a5fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>adipokine</topic><topic>amenorrhea</topic><topic>Animals</topic><topic>anorexia nervosa</topic><topic>Appetite - physiology</topic><topic>arcuate nucleus</topic><topic>Biological and medical sciences</topic><topic>Bone Remodeling - physiology</topic><topic>Cell Differentiation - physiology</topic><topic>cocaine amphetamine regulated transcript (CART)</topic><topic>Female genital diseases</topic><topic>glucose homeostasis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>hypothalamus</topic><topic>Hypothalamus - physiology</topic><topic>insulin signaling</topic><topic>Leptin - physiology</topic><topic>Medical sciences</topic><topic>melanocortin system</topic><topic>Metabolic diseases</topic><topic>Models, Biological</topic><topic>neuropeptide Y</topic><topic>Neurosecretory Systems - physiology</topic><topic>Non tumoral diseases</topic><topic>obese gene (OB)</topic><topic>Obesity</topic><topic>Osteoclasts - cytology</topic><topic>receptor for activated NFκB ligand (RANK)</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Receptors, Leptin</topic><topic>reproductive axis</topic><topic>sympathetic nervous system</topic><topic>ventromedial nucleus</topic><topic>β2 adrenergic receptor (β2-AR)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen Jr, M. 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In contrast, the sympathetic nervous system is the downstream pathway for regulating bone mass. Leptin, in regulating food intake and body weight, acts, in part, by inhibiting the synthesis of neuropeptide Y and its release from the hypothalamus. The leptin and insulin pathways may interact and may be important in the pathogenesis of the metabolic syndrome. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16463275</pmid><doi>10.1002/ajmg.a.31099</doi><tpages>10</tpages></addata></record> |
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| subjects | adipokine amenorrhea Animals anorexia nervosa Appetite - physiology arcuate nucleus Biological and medical sciences Bone Remodeling - physiology Cell Differentiation - physiology cocaine amphetamine regulated transcript (CART) Female genital diseases glucose homeostasis Gynecology. Andrology. Obstetrics Humans hypothalamus Hypothalamus - physiology insulin signaling Leptin - physiology Medical sciences melanocortin system Metabolic diseases Models, Biological neuropeptide Y Neurosecretory Systems - physiology Non tumoral diseases obese gene (OB) Obesity Osteoclasts - cytology receptor for activated NFκB ligand (RANK) Receptors, Cell Surface - physiology Receptors, Leptin reproductive axis sympathetic nervous system ventromedial nucleus β2 adrenergic receptor (β2-AR) |
| title | Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling |
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