Effect of oriented or random PEGylation on bioactivity of a factor VIII inhibitor blocking peptide

Peptides as therapeutic substances are efficient agents in the treatment of several diseases. However, they often have to be chemically modified in order to be suited as therapeutic agent. Conjugation to large carrier molecules is often required. A critical step is the identification of available si...

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Veröffentlicht in:Biotechnology and bioengineering 2006-03, Vol.93 (4), p.647-655
Hauptverfasser: Kopecky, Eva-Maria, Greinstetter, Sabine, Pabinger, Ingrid, Buchacher, Andrea, Römisch, Jürgen, Jungbauer, Alois
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Sprache:eng
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