Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum

The kinase activity of the thanatophoric dysplasia type II–fibroblast growth factor receptor 3 mutant (TDII–FGFR3) hampers its maturation. As a consequence, the immature receptor activates extracellular regulated kinases (ERKs) from the endoplasmic reticulum (ER), which leads to apoptosis. On the ot...

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Veröffentlicht in:	FEBS letters 2009-10, Vol.583 (19), p.3254-3258
Hauptverfasser:	Lievens, Patricia M-J., Zanolli, Elena, Garofalo, Silvio, Liboi, Elio
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating mutation Apoptosis - genetics cDNA representational difference analysis cDNA-RDA Cell Line Endoplasmic reticulum Endoplasmic Reticulum - enzymology Enzyme Activation ERK extracellular regulated kinases Extracellular Signal-Regulated MAP Kinases - metabolism FGFR3 Fibroblast growth factor receptor 3 Gene Expression Regulation Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Receptor, Fibroblast Growth Factor, Type 3 - metabolism Signal transduction Sprouty4 TDII Thanatophoric Dysplasia - enzymology Thanatophoric Dysplasia - genetics thanatophoric dysplasia type II Tyrosine kinase Up-Regulation
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