Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A

Microtubule‐stabilizing drugs able to delay the onset of CNS disease in an MS mouse model depends on altering both the lymphoid and myeloid cell compartments. The hallmark of autoimmunity is the activation and proliferation of autoreactive lymphocytes. Therefore, one potential strategy to treat auto...

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Veröffentlicht in:Journal of leukocyte biology 2009-10, Vol.86 (4), p.949-958
Hauptverfasser: Crume, Kevin P., O'Sullivan, David, Miller, John H., Northcote, Peter T., La Flamme, Anne C.
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Sprache:eng
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