Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study
The present study tested the hypothesis that cortical electroencephalographic (EEG) rhythms. change across normal elderly (Nold), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects as a function of the global cognitive level. Resting eyes-closed EEG data were recorded in 155...
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| Veröffentlicht in: | Clinical neurophysiology 2006-02, Vol.117 (2), p.252-268 |
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| creator | Babiloni, Claudio Binetti, Giuliano Cassetta, Emanuele Forno, Gloria Dal Percio, Claudio Del Ferreri, Florinda Ferri, Raffaele Frisoni, Giovanni Hirata, Koichi Lanuzza, Bartolo Miniussi, Carlo Moretti, Davide V. Nobili, Flavio Rodriguez, Guido Romani, Gian Luca Salinari, Serenella Rossini, Paolo M. |
| description | The present study tested the hypothesis that cortical electroencephalographic (EEG) rhythms. change across normal elderly (Nold), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects as a function of the global cognitive level.
Resting eyes-closed EEG data were recorded in 155 MCI, 193 mild AD, and 126 age-matched Nold subjects. EEG rhythms of interest were delta (2–4
Hz), theta (4–8
Hz), alpha 1 (8–10.5
Hz), alpha 2 (10.5–13
Hz), beta 1 (13–20
Hz), and beta 2 (20–30
Hz). EEG cortical sources were estimated by LORETA.
Occipital delta and alpha 1 sources in parietal, occipital, temporal, and ‘limbic’ areas had an intermediate magnitude in MCI subjects compared to mild AD and Nold subjects. These five EEG sources presented both linear and nonlinear (linear, exponential, logarithmic, and power) correlations with the global cognitive level (as revealed by mini mental state examination score) across all subjects.
Cortical EEG rhythms change in pathological aging as a function of the global cognitive level.
The present functional data on large populations support the ‘transitional hypothesis’ of a shadow zone across normality, pre-clinical stage of dementia (MCI), and AD. |
| doi_str_mv | 10.1016/j.clinph.2005.09.019 |
| format | Article |
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Resting eyes-closed EEG data were recorded in 155 MCI, 193 mild AD, and 126 age-matched Nold subjects. EEG rhythms of interest were delta (2–4
Hz), theta (4–8
Hz), alpha 1 (8–10.5
Hz), alpha 2 (10.5–13
Hz), beta 1 (13–20
Hz), and beta 2 (20–30
Hz). EEG cortical sources were estimated by LORETA.
Occipital delta and alpha 1 sources in parietal, occipital, temporal, and ‘limbic’ areas had an intermediate magnitude in MCI subjects compared to mild AD and Nold subjects. These five EEG sources presented both linear and nonlinear (linear, exponential, logarithmic, and power) correlations with the global cognitive level (as revealed by mini mental state examination score) across all subjects.
Cortical EEG rhythms change in pathological aging as a function of the global cognitive level.
The present functional data on large populations support the ‘transitional hypothesis’ of a shadow zone across normality, pre-clinical stage of dementia (MCI), and AD.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2005.09.019</identifier><identifier>PMID: 16377238</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Aging - pathology ; Alpha rhythm ; Alzheimer Disease - physiopathology ; Biological and medical sciences ; Brain Mapping ; Case-Control Studies ; Cerebral Cortex - physiopathology ; Cognition Disorders - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Electrodiagnosis. Electric activity recording ; Electroencephalography (EEG) ; Electroencephalography - classification ; Electroencephalography - methods ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Low resolution brain electromagnetic tomography (LORETA) ; Male ; Medical sciences ; Mental Status Schedule - statistics & numerical data ; Middle Aged ; Mild Alzheimer's disease (mild AD) ; Mild cognitive impairment (MCI) ; Nervous system ; Neurology ; Retrospective Studies ; Signal Processing, Computer-Assisted ; Spectrum Analysis ; Statistics as Topic</subject><ispartof>Clinical neurophysiology, 2006-02, Vol.117 (2), p.252-268</ispartof><rights>2005 International Federation of Clinical Neurophysiology</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-8f8445a8b11087bfbe8c938daafb54ea8ba81567a71f2bdc8e93ec1436fa751a3</citedby><cites>FETCH-LOGICAL-c502t-8f8445a8b11087bfbe8c938daafb54ea8ba81567a71f2bdc8e93ec1436fa751a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1388245705003871$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17562674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16377238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babiloni, Claudio</creatorcontrib><creatorcontrib>Binetti, Giuliano</creatorcontrib><creatorcontrib>Cassetta, Emanuele</creatorcontrib><creatorcontrib>Forno, Gloria Dal</creatorcontrib><creatorcontrib>Percio, Claudio Del</creatorcontrib><creatorcontrib>Ferreri, Florinda</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><creatorcontrib>Frisoni, Giovanni</creatorcontrib><creatorcontrib>Hirata, Koichi</creatorcontrib><creatorcontrib>Lanuzza, Bartolo</creatorcontrib><creatorcontrib>Miniussi, Carlo</creatorcontrib><creatorcontrib>Moretti, Davide V.</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><creatorcontrib>Rodriguez, Guido</creatorcontrib><creatorcontrib>Romani, Gian Luca</creatorcontrib><creatorcontrib>Salinari, Serenella</creatorcontrib><creatorcontrib>Rossini, Paolo M.</creatorcontrib><title>Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>The present study tested the hypothesis that cortical electroencephalographic (EEG) rhythms. change across normal elderly (Nold), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects as a function of the global cognitive level.
Resting eyes-closed EEG data were recorded in 155 MCI, 193 mild AD, and 126 age-matched Nold subjects. EEG rhythms of interest were delta (2–4
Hz), theta (4–8
Hz), alpha 1 (8–10.5
Hz), alpha 2 (10.5–13
Hz), beta 1 (13–20
Hz), and beta 2 (20–30
Hz). EEG cortical sources were estimated by LORETA.
Occipital delta and alpha 1 sources in parietal, occipital, temporal, and ‘limbic’ areas had an intermediate magnitude in MCI subjects compared to mild AD and Nold subjects. These five EEG sources presented both linear and nonlinear (linear, exponential, logarithmic, and power) correlations with the global cognitive level (as revealed by mini mental state examination score) across all subjects.
Cortical EEG rhythms change in pathological aging as a function of the global cognitive level.
The present functional data on large populations support the ‘transitional hypothesis’ of a shadow zone across normality, pre-clinical stage of dementia (MCI), and AD.</description><subject>Aged</subject><subject>Aging - pathology</subject><subject>Alpha rhythm</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electroencephalography (EEG)</subject><subject>Electroencephalography - classification</subject><subject>Electroencephalography - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Low resolution brain electromagnetic tomography (LORETA)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Status Schedule - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Mild Alzheimer's disease (mild AD)</subject><subject>Mild cognitive impairment (MCI)</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Retrospective Studies</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Spectrum Analysis</subject><subject>Statistics as Topic</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2L1TAUhosozjj6D0Sy0V1r0jZN6kKQwS8YcKGuw2l60ubSJjVJB-6_N2MvzM7VOXCe9-XwFMVrRitGWff-VOnFum2uakp5RfuKsv5Jcc2kqEvZ8_pp3hspy7rl4qp4EeOJUipoWz8vrljXCFE38rqIP_0eNEbiDdE-JKthIWE-p3mNRM_gJiQQCRCzO52sdwc4OZvsPRK7bmDDii4R68gGafaLn_6VwGTd9CEn133JtRnBQGLax_PL4pmBJeKry7wpfn_5_Ov2W3n34-v32093pea0TqU0sm05yIExKsVgBpS6b-QIYAbeYj6AZLwTIJiph1FL7BvUrG06A4IzaG6Kd0fvFvyfHWNSq40alwUc-j2qTnSiZV2fwfYAdfAxBjRqC3aFcFaMqgfZ6qQO2epBtqK9yrJz7M2lfx9WHB9DF7sZeHsBIGYlJoDTNj5ygnd1fiFzHw8Os417i0FFbdFpHG1AndTo7f8_-Qsw_KHg</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Babiloni, Claudio</creator><creator>Binetti, Giuliano</creator><creator>Cassetta, Emanuele</creator><creator>Forno, Gloria Dal</creator><creator>Percio, Claudio Del</creator><creator>Ferreri, Florinda</creator><creator>Ferri, Raffaele</creator><creator>Frisoni, Giovanni</creator><creator>Hirata, Koichi</creator><creator>Lanuzza, Bartolo</creator><creator>Miniussi, Carlo</creator><creator>Moretti, Davide V.</creator><creator>Nobili, Flavio</creator><creator>Rodriguez, Guido</creator><creator>Romani, Gian Luca</creator><creator>Salinari, Serenella</creator><creator>Rossini, Paolo M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study</title><author>Babiloni, Claudio ; Binetti, Giuliano ; Cassetta, Emanuele ; Forno, Gloria Dal ; Percio, Claudio Del ; Ferreri, Florinda ; Ferri, Raffaele ; Frisoni, Giovanni ; Hirata, Koichi ; Lanuzza, Bartolo ; Miniussi, Carlo ; Moretti, Davide V. ; Nobili, Flavio ; Rodriguez, Guido ; Romani, Gian Luca ; Salinari, Serenella ; Rossini, Paolo M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-8f8445a8b11087bfbe8c938daafb54ea8ba81567a71f2bdc8e93ec1436fa751a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aging - pathology</topic><topic>Alpha rhythm</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Case-Control Studies</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electroencephalography (EEG)</topic><topic>Electroencephalography - classification</topic><topic>Electroencephalography - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Low resolution brain electromagnetic tomography (LORETA)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Status Schedule - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Mild Alzheimer's disease (mild AD)</topic><topic>Mild cognitive impairment (MCI)</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Retrospective Studies</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Spectrum Analysis</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babiloni, Claudio</creatorcontrib><creatorcontrib>Binetti, Giuliano</creatorcontrib><creatorcontrib>Cassetta, Emanuele</creatorcontrib><creatorcontrib>Forno, Gloria Dal</creatorcontrib><creatorcontrib>Percio, Claudio Del</creatorcontrib><creatorcontrib>Ferreri, Florinda</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><creatorcontrib>Frisoni, Giovanni</creatorcontrib><creatorcontrib>Hirata, Koichi</creatorcontrib><creatorcontrib>Lanuzza, Bartolo</creatorcontrib><creatorcontrib>Miniussi, Carlo</creatorcontrib><creatorcontrib>Moretti, Davide V.</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><creatorcontrib>Rodriguez, Guido</creatorcontrib><creatorcontrib>Romani, Gian Luca</creatorcontrib><creatorcontrib>Salinari, Serenella</creatorcontrib><creatorcontrib>Rossini, Paolo M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babiloni, Claudio</au><au>Binetti, Giuliano</au><au>Cassetta, Emanuele</au><au>Forno, Gloria Dal</au><au>Percio, Claudio Del</au><au>Ferreri, Florinda</au><au>Ferri, Raffaele</au><au>Frisoni, Giovanni</au><au>Hirata, Koichi</au><au>Lanuzza, Bartolo</au><au>Miniussi, Carlo</au><au>Moretti, Davide V.</au><au>Nobili, Flavio</au><au>Rodriguez, Guido</au><au>Romani, Gian Luca</au><au>Salinari, Serenella</au><au>Rossini, Paolo M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>117</volume><issue>2</issue><spage>252</spage><epage>268</epage><pages>252-268</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>The present study tested the hypothesis that cortical electroencephalographic (EEG) rhythms. change across normal elderly (Nold), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects as a function of the global cognitive level.
Resting eyes-closed EEG data were recorded in 155 MCI, 193 mild AD, and 126 age-matched Nold subjects. EEG rhythms of interest were delta (2–4
Hz), theta (4–8
Hz), alpha 1 (8–10.5
Hz), alpha 2 (10.5–13
Hz), beta 1 (13–20
Hz), and beta 2 (20–30
Hz). EEG cortical sources were estimated by LORETA.
Occipital delta and alpha 1 sources in parietal, occipital, temporal, and ‘limbic’ areas had an intermediate magnitude in MCI subjects compared to mild AD and Nold subjects. These five EEG sources presented both linear and nonlinear (linear, exponential, logarithmic, and power) correlations with the global cognitive level (as revealed by mini mental state examination score) across all subjects.
Cortical EEG rhythms change in pathological aging as a function of the global cognitive level.
The present functional data on large populations support the ‘transitional hypothesis’ of a shadow zone across normality, pre-clinical stage of dementia (MCI), and AD.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16377238</pmid><doi>10.1016/j.clinph.2005.09.019</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aging - pathology Alpha rhythm Alzheimer Disease - physiopathology Biological and medical sciences Brain Mapping Case-Control Studies Cerebral Cortex - physiopathology Cognition Disorders - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electrodiagnosis. Electric activity recording Electroencephalography (EEG) Electroencephalography - classification Electroencephalography - methods Female Humans Investigative techniques, diagnostic techniques (general aspects) Low resolution brain electromagnetic tomography (LORETA) Male Medical sciences Mental Status Schedule - statistics & numerical data Middle Aged Mild Alzheimer's disease (mild AD) Mild cognitive impairment (MCI) Nervous system Neurology Retrospective Studies Signal Processing, Computer-Assisted Spectrum Analysis Statistics as Topic |
| title | Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study |
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