MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes

GLUT4 shows decreased levels in failing human adult hearts. We speculated that GLUT4 expression in cardiac muscle may be fine-tuned by microRNAs. Forced expression of miR-133 decreased GLUT4 expression and reduced insulin-mediated glucose uptake in cardiomyocytes. A computational miRNA target predic...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-11, Vol.389 (2), p.315-320
Hauptverfasser:	Horie, Takahiro, Ono, Koh, Nishi, Hitoo, Iwanaga, Yoshitaka, Nagao, Kazuya, Kinoshita, Minako, Kuwabara, Yasuhide, Takanabe, Rieko, Hasegawa, Koji, Kita, Toru, Kimura, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cardiomyocyte Gene Expression Regulation Glucose Transporter Type 4 - genetics GLUT4 Heart Failure - genetics Heart Failure - metabolism Humans Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - metabolism Kruppel-Like Transcription Factors - metabolism MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Molecular Sequence Data Myocytes, Cardiac - metabolism Rats Rats, Inbred Dahl
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