CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells

Abstract Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinenset...

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Veröffentlicht in:	Toxicology (Amsterdam) 2009-10, Vol.264 (3), p.162-170
Hauptverfasser:	Androutsopoulos, Vasilis P, Ruparelia, Ketan, Arroo, Randolph R.J, Tsatsakis, Aristidis M, Spandidos, Demetrios A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - pathology Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Biotransformation Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects CYP1A1 CYP1A2 CYP1B1 Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1B1 Dealkylation Diet Dose-Response Relationship, Drug Emergency Enzyme Inhibitors - pharmacology Female Flavones - pharmacology Flavonoids Flavonoids - metabolism Flavonoids - pharmacology Gynecology. Andrology. Obstetrics Humans Hydroxylation Kinetics Mammary gland diseases MDA-MB-468 cells Medical sciences Metabolism Plant poisons toxicology Recombinant Proteins - metabolism Toxicology Tumors
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