Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction

Understanding external factors that determine cellular phenotypic responses is of key interest in the field of biomaterials. Currently, material surface characteristics, protein adsorption and cellular phenotypic responses are all considered to be interrelated and ultimately determine the biocompati...

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Veröffentlicht in:	Biomaterials 2006-06, Vol.27 (16), p.3096-3108
Hauptverfasser:	Allen, Lorcan T., Tosetto, Miriam, Miller, Ian S., O’Connor, Darran P., Penney, Stephen C., Lynch, Iseult, Keenan, Alan K., Pennington, Stephen R., Dawson, Kenneth A., Gallagher, William M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Acrylamides - metabolism Acrylamides - pharmacology Adsorption Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biocompatible Materials - pharmacology Blood Proteins - chemistry Blood Proteins - metabolism Blood Proteins - pharmacology Cell Adhesion - drug effects Cell migration Cell Movement - drug effects Cell signalling Culture Media - chemistry Culture Media - pharmacology Fibronectin Fibronectins - chemistry Fibronectins - metabolism Fibronectins - pharmacology Focal adhesion Focal Adhesion Kinase 1 - metabolism Focal Adhesions - drug effects Gene Expression - drug effects HeLa Cells Humans Hydrophobic and Hydrophilic Interactions Microscopy, Confocal Microscopy, Fluorescence Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation - drug effects Polystyrenes - chemistry Polystyrenes - metabolism Polystyrenes - pharmacology Protein adsorption Protein Binding Serum Albumin - chemistry Serum Albumin - metabolism Serum Albumin - pharmacology Signal Transduction - drug effects Surface hydrophobicity Surface Properties
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