EFFECT OF ALCOHOL ON CYTOCHROME P450 ARACHIDONIC ACID METABOLISM AND BLOOD PRESSURE IN RATS AND ITS MODULATION BY RED WINE POLYPHENOLICS

SUMMARY 1 Alcohol‐induced hypertension is well recognized with clear evidence for a direct pressor effect of chronic alcohol consumption provided by a number of intervention studies in humans. In experimental animals, the effect of alcohol on blood pressure is less consistent; however, in Sprague‐Da...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2006-03, Vol.33 (3), p.183-188
Hauptverfasser:	Cowpland, Christine, Su, Gloria M, Murray, Michael, Puddey, Ian B, Croft, Kevin D
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohol Animals Arachidonic Acid - metabolism blood pressure Blood Pressure - drug effects Blotting, Western Body Weight - physiology Central Nervous System Depressants - pharmacology Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 CYP4A - metabolism Cytochrome P-450 Enzyme System - metabolism cytochrome P450 Ethanol - pharmacology Flavonoids - pharmacology Hydroxyeicosatetraenoic Acids - metabolism Isoprostanes - metabolism Kidney - drug effects Kidney - enzymology Liver - drug effects Liver - enzymology Male Microsomes - drug effects Microsomes - enzymology Phenols - pharmacology Polyphenols Rats Rats, Sprague-Dawley red wine polyphenols Wine - analysis
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