RNA interference targeting Akt promotes apoptosis in hypoxia-exposed human neuroblastoma cells

Overactivation of the PI3 kinase/Akt pathway plays an essential role in the development and progression of various tumors. Akt is a key component of this pathway and hyperactivated in different tumors including neuroblastoma and glioma. In the present study, we tested the therapeutic efficacy of siR...

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Veröffentlicht in:	Brain research 2006-01, Vol.1070 (1), p.24-30
Hauptverfasser:	Liu, Xiu-Huai, Yu, Erik Z., Li, Ying-Yue, Rollwagen, Florence M., Kagan, Elliott
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Anoxia Apoptosis Biological and medical sciences Cell Hypoxia Cell Line, Tumor Humans Medical sciences Molecular Sequence Data Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - physiopathology Neurology Oxygen - pharmacology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA Interference RNAi Tumors of the nervous system. Phacomatoses Up-Regulation
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