RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

Pyrimidinol carboxylic acids were designed as inhibitors of HIV-1 RNase H function. These molecules can coordinate to two divalent metal ions in the RNase H active site. Inhibition of enzymatic activity was measured in a biochemical assay, but no antiviral effect was observed. Binding was demonstrat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2009-10, Vol.52 (19), p.5781-5784
Hauptverfasser:	Kirschberg, Thorsten A, Balakrishnan, Mini, Squires, Neil H, Barnes, Tiffany, Brendza, Katherine M, Chen, Xiaowu, Eisenberg, Eugene J, Jin, Weili, Kutty, Nilima, Leavitt, Stephanie, Liclican, Albert, Liu, Qi, Liu, Xiaohong, Mak, John, Perry, Jason K, Wang, Michael, Watkins, William J, Lansdon, Eric B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Carboxylic Acids Catalytic Domain Drug Design HIV Reverse Transcriptase - antagonists & inhibitors Humans Medical sciences Pharmacology. Drug treatments Protein Binding Pyrimidines - chemistry Pyrimidines - pharmacology Ribonuclease H - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!