Anti-platelet activity of KR-32560, a novel sodium/hydrogen exchanger-1 inhibitor

We investigated the anti-platelet effect of a newly synthesized guanidine derivative KR-32560, a sodium/hydrogen exchanger-1 (NHE-1) inhibitor, together with the elucidation of the possible mode of action. KR-32560 concentration dependently inhibited the aggregation of washed rabbit platelets induce...

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Veröffentlicht in:	Pharmacological research 2006-03, Vol.53 (3), p.265-270
Hauptverfasser:	Lee, Kyung-Sup, Jin, Yong-Ri, Lee, Jung-Jin, Lim, Yong, Son, Dong-Ju, Lee, Chong-Kil, Yi, Kyu-Yang, Yoo, Sung-Eun, Shin, Hwa-Sup, Yun, Yeo-Pyo
Format:	Artikel
Sprache:	eng
Schlagworte:	[Ca 2+] i mobilization Animals Arachidonic Acid - metabolism Arachidonic Acid - pharmacology Arachidonic acid liberation Blood Platelets - drug effects Blood Platelets - enzymology Calcium - metabolism Collagen - pharmacology Dose-Response Relationship, Drug Guanidines - pharmacology In Vitro Techniques KR-32560 Male Platelet Aggregation Platelet Aggregation Inhibitors - pharmacology Rabbits Serotonin - metabolism Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium–hydrogen exchanger-1 Thromboxane B2 - metabolism Thromboxane-A Synthase - antagonists & inhibitors Thromboxane-A Synthase - metabolism
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