IGH and IGK gene rearrangements as PCR targets for pediatric Burkitt's lymphoma and mature B-ALL MRD analysis

We recently reported that minimal residual disease (MRD) and minimal disseminated disease (MDD), assessed by long-distance PCR (LD-PCR) for t(8;14), are negative prognostic factors in mature B-cell acute lymphoblastic leukemia (B-ALL) and in Burkitt's lymphoma (BL). However, t(8;14) is detectab...

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Veröffentlicht in:	Laboratory investigation 2009-10, Vol.89 (10), p.1182-1186
Hauptverfasser:	Lovisa, Federica, Mussolin, Lara, Corral, Lilia, Pillon, Marta, Cazzaniga, Giovanni, Biondi, Andrea, Rosolen, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	B-cell acute lymphoblastic leukemia Biological and medical sciences Burkitt Lymphoma - genetics Burkitt's lymphoma Child clonality Gene Rearrangement, B-Lymphocyte, Heavy Chain Gene Rearrangement, B-Lymphocyte, Light Chain Hematologic and hematopoietic diseases Hematology Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin kappa-Chains - genetics immunoglobulin rearrangement Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Leukemia, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health minimal residual disease Neoplasm, Residual Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction technical-report
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