Mitotic division of the mammalian Golgi apparatus
Successful cell reproduction requires faithful duplication and proper segregation of cellular contents, including not only the genome but also intracellular organelles. Since the Golgi apparatus is an essential organelle of the secretory pathway, its accurate inheritance is therefore of importance t...
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Veröffentlicht in: | Seminars in cell & developmental biology 2009-09, Vol.20 (7), p.810-816 |
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creator | Wei, Jen-Hsuan Seemann, Joachim |
description | Successful cell reproduction requires faithful duplication and proper segregation of cellular contents, including not only the genome but also intracellular organelles. Since the Golgi apparatus is an essential organelle of the secretory pathway, its accurate inheritance is therefore of importance to sustain cellular function. Regulation of Golgi division and its coordination with cell cycle progression involves a series of sequential events that are subjected to a precise spatiotemporal control. Here, we summarize the current knowledge about the underlying mechanisms, the molecular players and the biological relevance of this process, particularly in mammalian cells, and discuss the unsolved problems and future perspectives opened by the recent studies. |
doi_str_mv | 10.1016/j.semcdb.2009.03.010 |
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source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
subjects | Animals Endoplasmic Reticulum Golgi Golgi Apparatus Humans Mammals Mitosis Organelle inheritance Ribbon Spindle Spindle Apparatus |
title | Mitotic division of the mammalian Golgi apparatus |
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