$Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma$

Evidence of a Role of Tumor Necrosis Factor α in Refractory Asthma

Patients with severe asthma are distinct from patients with milder forms of the disease. Peripheral-blood monocytes from patients with severe asthma were shown to have enhanced expression of markers associated with tumor necrosis factor α (TNF-α). In a pilot, placebo-controlled, crossover study, the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2006-02, Vol.354 (7), p.697-708
Hauptverfasser:	Berry, Mike A, Hargadon, Beverley, Shelley, Maria, Parker, Debbie, Shaw, Dominick E, Green, Ruth H, Bradding, Peter, Brightling, Christopher E, Wardlaw, Andrew J, Pavord, Ian D
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - biosynthesis ADAM17 Protein Adolescent Adult Aged Asthma - drug therapy Asthma - metabolism Asthma - physiopathology Biomarkers - metabolism Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - metabolism Case-Control Studies Cross-Over Studies Double-Blind Method Etanercept Female Forced Expiratory Volume - drug effects Humans Immunoglobulin G - therapeutic use Immunologic Factors - therapeutic use Male Methacholine Chloride Middle Aged Monocytes - metabolism Pilot Projects Receptors, Tumor Necrosis Factor - therapeutic use Receptors, Tumor Necrosis Factor, Type I - biosynthesis Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!