Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology

Metabolic 'oligosaccharide engineering' methods based on N -acetyl- D -mannosamine (ManNAc) analogs allow the glycocalyx of living cells to be remodeled 1 , 2 , 3 . Herein we report the analog Ac 5 ManNTGc ( 1 ) that enables thiols to be expressed in surface sialic acids. By locating this...

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Veröffentlicht in:	Nature chemical biology 2006-03, Vol.2 (3), p.149-152
Hauptverfasser:	Sampathkumar, Srinivasa-Gopalan, Li, Adrienne V, Jones, Mark B, Sun, Zhonghui, Yarema, Kevin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids beta Catenin - metabolism Biochemical Engineering Biochemistry Bioorganic Chemistry Biotechnology Carbohydrates Cell adhesion & migration Cell Adhesion - drug effects Cell Adhesion - physiology Cell Biology Cell Differentiation - physiology Cell Membrane - physiology Cell morphology Cellular biology Chemistry Chemistry/Food Science Gold Gold - chemistry Hexosamines - chemistry Hexosamines - metabolism Humans Jurkat Cells letter Ligands Metabolism Molecular Conformation N-Acetylneuraminic Acid - biosynthesis N-Acetylneuraminic Acid - chemistry Stem cells Stem Cells - chemistry Stem Cells - physiology Substrates Sugar Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - metabolism Sulfhydryl Compounds - pharmacology Surface Properties Up-Regulation
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