Cell cycle and cell death regulation of neural progenitor cells in the 5-azacytidine (5AzC)-treated developing fetal brain

In the developing brain, neural progenitor cells are susceptible to many extrinsic stresses, including DNA damage. We treated pregnant rats with 5-azacytidine (5AzC), a DNA demethylating and damaging agent, to investigate the cellular responses of the fetal brain, focusing on the regulation of proli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental neurology 2006-03, Vol.198 (1), p.154-166
Hauptverfasser:	Ueno, Masaki, Katayama, Kei-ichi, Yamauchi, Hirofumi, Nakayama, Hiroyuki, Doi, Kunio
Format:	Artikel
Sprache:	eng
Schlagworte:	5-azacytidine Animals Apoptosis Azacitidine - pharmacology Biological and medical sciences Blotting, Western - methods Brain - cytology Brain - drug effects Brain - embryology Bromodeoxyuridine - metabolism Caspase 3 Caspases - metabolism Cell Cycle - drug effects Cell cycle arrest Cell Death - drug effects Development. Senescence. Regeneration. Transplantation DNA damage DNA Fragmentation - drug effects Embryo, Mammalian Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Histones - metabolism Interkinetic nuclear migration Isolated neuron and nerve. Neuroglia Microarray Analysis - methods Mitotic catastrophe Models, Biological Neural progenitor cell Neurons - cytology Neurons - drug effects p53 Pregnancy Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Stem Cells - cytology Stem Cells - drug effects Time Factors Tumor Suppressor Protein p53 - metabolism Ventricular zone Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!