Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

Deficits of neurotrophic support caused by reduced levels of brain‐derived neurotrophic factor (BDNF) have been implicated in the selective vulnerability of striatal neurones in Huntington's disease (HD). Therapeutic strategies based on BDNF administration have been proposed to slow or prevent...

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Veröffentlicht in:	The European journal of neuroscience 2006-02, Vol.23 (3), p.649-658
Hauptverfasser:	Ginés, Silvia, Bosch, Miquel, Marco, Sonia, Gavaldà, Núria, Díaz-Hernández, Miguel, Lucas, José J., Canals, Josep M., Alberch, Jordi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Blotting, Western - methods Brain - metabolism Brain - pathology Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Cell Count - methods Cells, Cultured Disease Models, Animal Enzyme-Linked Immunosorbent Assay - methods Exons - genetics Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Humans huntingtin Huntingtin Protein Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Huntington's disease brain In Situ Hybridization - methods Mice Mice, Transgenic Mutant Proteins - metabolism Nerve Tissue Proteins - metabolism neurodegenerative disease Neurons - drug effects Neurons - metabolism neuroprotection neurotrophic factor Nuclear Proteins - metabolism Postmortem Changes Receptor, trkB - genetics Receptor, trkB - metabolism RNA, Messenger - metabolism striatum
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