Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death Paul A. Heidenreich, John A. Spertus, Philip G. Jones, William S. Weintraub, John S. Rumsfeld, Saif S. Rathore, Eric D. Peterson, Frederick A. Masoudi, Harlan M. Krumholz, Edward P. Havranek, Mark W. Conard, Rand...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2006-02, Vol.47 (4), p.752-756 |
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| creator | Heidenreich, Paul A. Spertus, John A. Jones, Philip G. Weintraub, William S. Rumsfeld, John S. Rathore, Saif S. Peterson, Eric D. Masoudi, Frederick A. Krumholz, Harlan M. Havranek, Edward P. Conard, Mark W. Williams, Randall E. |
| description | Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Paul A. Heidenreich, John A. Spertus, Philip G. Jones, William S. Weintraub, John S. Rumsfeld, Saif S. Rathore, Eric D. Peterson, Frederick A. Masoudi, Harlan M. Krumholz, Edward P. Havranek, Mark W. Conard, Randall E. Williams, for the Cardiovascular Outcomes Research Consortium
To test the hypothesis that the Kansas City Cardiomyopathy Questionnaire (KCCQ) provides prognostic information independent of other clinical data, we evaluated 505 heart failure (HF) patients who had an ejection fraction |
| doi_str_mv | 10.1016/j.jacc.2005.11.021 |
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Paul A. Heidenreich, John A. Spertus, Philip G. Jones, William S. Weintraub, John S. Rumsfeld, Saif S. Rathore, Eric D. Peterson, Frederick A. Masoudi, Harlan M. Krumholz, Edward P. Havranek, Mark W. Conard, Randall E. Williams, for the Cardiovascular Outcomes Research Consortium
To test the hypothesis that the Kansas City Cardiomyopathy Questionnaire (KCCQ) provides prognostic information independent of other clinical data, we evaluated 505 heart failure (HF) patients who had an ejection fraction <40%. At 12 months, among patients with a KCCQ score <25, 37% had been admitted for HF and 20% had died, compared with 7% (admissions) and 5% (death) of those with a KCCQ score ≥75 (p < 0.0001 for both comparisons). In sequential multivariable models adjusting for clinical variables, six-minute walk, and B-type natriuretic peptide levels, the KCCQ score remained significantly associated with survival free of HF hospitalization.
We tested the hypothesis that one health status measure, the Kansas City Cardiomyopathy Questionnaire (KCCQ), provides prognostic information independent of other clinical data in outpatients with heart failure (HF).
Health status measures are used to describe a patient’s clinical condition and have been shown to predict mortality in some populations. Their prognostic value may be particularly useful among patients with HF for identifying candidates for disease management in whom increased care may reduce hospitalizations and prevent death.
We evaluated 505 HF patients from 13 outpatient clinics who had an ejection fraction <40% using the KCCQ summary score. Proportional hazards regression was used to evaluate the association between the KCCQ summary score (range, 0 to 100; higher scores indicate better health status) and the primary outcome of death or HF admission, adjusting for baseline patient characteristics, 6-min walk distance, and B-type natriuretic peptide (BNP).
The mean age was 61 years, 76% of patients were male, 51% had an ischemic HF etiology, and 5% were New York Heart Association functional class IV. At 12 months, among the 9% of patients with a KCCQ score <25, 37% had been admitted for HF and 20% had died, compared with 7% (HF admissions) and 5% (death) of those with a KCCQ score ≥75 (33% of patients, p < 0.0001 for both comparisons). In sequential multivariable models adjusting for clinical variables, 6-min walk, and BNP levels, the KCCQ score remained significantly associated with survival free of HF hospitalization.
A low KCCQ score is an independent predictor of poor prognosis in outpatients with HF.]]></description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2005.11.021</identifier><identifier>PMID: 16487840</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age ; Ambulatory Care ; Biological and medical sciences ; Blood pressure ; Body mass index ; Cardiology ; Cardiology. Vascular system ; Cardiomyopathy ; Confidence intervals ; Diabetes ; Disease-Free Survival ; Drug therapy ; Female ; Health Status ; Heart ; Heart attacks ; Heart failure ; Heart Failure - complications ; Heart Failure - mortality ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hospitalization ; Humans ; Hypertension ; Male ; Medical prognosis ; Medical sciences ; Middle Aged ; Mortality ; Older people ; Patients ; Peptides ; Prognosis ; Proportional Hazards Models ; Quality of Life ; Questionnaires ; Risk Factors ; Studies ; Surveys and Questionnaires ; Survival Rate</subject><ispartof>Journal of the American College of Cardiology, 2006-02, Vol.47 (4), p.752-756</ispartof><rights>2006 American College of Cardiology Foundation</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 21, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-c2fa663226a4a94e11ce37188a0b302abe6baf0107b27e1beb022503e8444e383</citedby><cites>FETCH-LOGICAL-c556t-c2fa663226a4a94e11ce37188a0b302abe6baf0107b27e1beb022503e8444e383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2005.11.021$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17534558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16487840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heidenreich, Paul A.</creatorcontrib><creatorcontrib>Spertus, John A.</creatorcontrib><creatorcontrib>Jones, Philip G.</creatorcontrib><creatorcontrib>Weintraub, William S.</creatorcontrib><creatorcontrib>Rumsfeld, John S.</creatorcontrib><creatorcontrib>Rathore, Saif S.</creatorcontrib><creatorcontrib>Peterson, Eric D.</creatorcontrib><creatorcontrib>Masoudi, Frederick A.</creatorcontrib><creatorcontrib>Krumholz, Harlan M.</creatorcontrib><creatorcontrib>Havranek, Edward P.</creatorcontrib><creatorcontrib>Conard, Mark W.</creatorcontrib><creatorcontrib>Williams, Randall E.</creatorcontrib><creatorcontrib>Cardiovascular Outcomes Research Consortium</creatorcontrib><title>Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description><![CDATA[Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Paul A. Heidenreich, John A. Spertus, Philip G. Jones, William S. Weintraub, John S. Rumsfeld, Saif S. Rathore, Eric D. Peterson, Frederick A. Masoudi, Harlan M. Krumholz, Edward P. Havranek, Mark W. Conard, Randall E. Williams, for the Cardiovascular Outcomes Research Consortium
To test the hypothesis that the Kansas City Cardiomyopathy Questionnaire (KCCQ) provides prognostic information independent of other clinical data, we evaluated 505 heart failure (HF) patients who had an ejection fraction <40%. At 12 months, among patients with a KCCQ score <25, 37% had been admitted for HF and 20% had died, compared with 7% (admissions) and 5% (death) of those with a KCCQ score ≥75 (p < 0.0001 for both comparisons). In sequential multivariable models adjusting for clinical variables, six-minute walk, and B-type natriuretic peptide levels, the KCCQ score remained significantly associated with survival free of HF hospitalization.
We tested the hypothesis that one health status measure, the Kansas City Cardiomyopathy Questionnaire (KCCQ), provides prognostic information independent of other clinical data in outpatients with heart failure (HF).
Health status measures are used to describe a patient’s clinical condition and have been shown to predict mortality in some populations. Their prognostic value may be particularly useful among patients with HF for identifying candidates for disease management in whom increased care may reduce hospitalizations and prevent death.
We evaluated 505 HF patients from 13 outpatient clinics who had an ejection fraction <40% using the KCCQ summary score. Proportional hazards regression was used to evaluate the association between the KCCQ summary score (range, 0 to 100; higher scores indicate better health status) and the primary outcome of death or HF admission, adjusting for baseline patient characteristics, 6-min walk distance, and B-type natriuretic peptide (BNP).
The mean age was 61 years, 76% of patients were male, 51% had an ischemic HF etiology, and 5% were New York Heart Association functional class IV. At 12 months, among the 9% of patients with a KCCQ score <25, 37% had been admitted for HF and 20% had died, compared with 7% (HF admissions) and 5% (death) of those with a KCCQ score ≥75 (33% of patients, p < 0.0001 for both comparisons). In sequential multivariable models adjusting for clinical variables, 6-min walk, and BNP levels, the KCCQ score remained significantly associated with survival free of HF hospitalization.
A low KCCQ score is an independent predictor of poor prognosis in outpatients with HF.]]></description><subject>Age</subject><subject>Ambulatory Care</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathy</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Disease-Free Survival</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Health Status</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Older people</subject><subject>Patients</subject><subject>Peptides</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>Survival Rate</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7uzqH_AgAdFbt6mkk_SAl2V1dxYWFvzAY6jOVLNpe7rHJC3orzfDDCx48BTI-9RL8RRjr0DUIMC8H-oBva-lELoGqIWEJ2wFWreV0mv7lK2EVboCsbZn7DylQQhhWlg_Z2dgmta2jVix7xvCMT_wLxnzkvjtlqYc-kCJlyBmfo1hXCLx-yXvMYeSJo6Zfw7pB-_nyDdz2oeMY_hT0nni5esjYX54wZ71OCZ6eXov2LfrT1-vNtXd_c3t1eVd5bU2ufKyR2OUlAYbXDcE4ElZaFsUnRISOzId9gKE7aQl6KgTUmqhqG2ahlSrLti7Y-8-zj8XStntQvI0jjjRvCRnrDG2taqAb_4Bh3mJU9nNgRYGjC1thZJHysc5pUi928eww_jbgXAH6W5wB-nuIN0BuCK9DL0-VS_djraPIyfLBXh7AjB5HPuIkw_pkbNaNeVshftw5KgY-xUouuSLck_bEMlnt53D__b4C7ACnoI</recordid><startdate>20060221</startdate><enddate>20060221</enddate><creator>Heidenreich, Paul A.</creator><creator>Spertus, John A.</creator><creator>Jones, Philip G.</creator><creator>Weintraub, William S.</creator><creator>Rumsfeld, John S.</creator><creator>Rathore, Saif S.</creator><creator>Peterson, Eric D.</creator><creator>Masoudi, Frederick A.</creator><creator>Krumholz, Harlan M.</creator><creator>Havranek, Edward P.</creator><creator>Conard, Mark W.</creator><creator>Williams, Randall E.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20060221</creationdate><title>Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death</title><author>Heidenreich, Paul A. ; Spertus, John A. ; Jones, Philip G. ; Weintraub, William S. ; Rumsfeld, John S. ; Rathore, Saif S. ; Peterson, Eric D. ; Masoudi, Frederick A. ; Krumholz, Harlan M. ; Havranek, Edward P. ; Conard, Mark W. ; Williams, Randall E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-c2fa663226a4a94e11ce37188a0b302abe6baf0107b27e1beb022503e8444e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Age</topic><topic>Ambulatory Care</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathy</topic><topic>Confidence intervals</topic><topic>Diabetes</topic><topic>Disease-Free Survival</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Health Status</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Older people</topic><topic>Patients</topic><topic>Peptides</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heidenreich, Paul A.</creatorcontrib><creatorcontrib>Spertus, John A.</creatorcontrib><creatorcontrib>Jones, Philip G.</creatorcontrib><creatorcontrib>Weintraub, William S.</creatorcontrib><creatorcontrib>Rumsfeld, John S.</creatorcontrib><creatorcontrib>Rathore, Saif S.</creatorcontrib><creatorcontrib>Peterson, Eric D.</creatorcontrib><creatorcontrib>Masoudi, Frederick A.</creatorcontrib><creatorcontrib>Krumholz, Harlan M.</creatorcontrib><creatorcontrib>Havranek, Edward P.</creatorcontrib><creatorcontrib>Conard, Mark W.</creatorcontrib><creatorcontrib>Williams, Randall E.</creatorcontrib><creatorcontrib>Cardiovascular Outcomes Research Consortium</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heidenreich, Paul A.</au><au>Spertus, John A.</au><au>Jones, Philip G.</au><au>Weintraub, William S.</au><au>Rumsfeld, John S.</au><au>Rathore, Saif S.</au><au>Peterson, Eric D.</au><au>Masoudi, Frederick A.</au><au>Krumholz, Harlan M.</au><au>Havranek, Edward P.</au><au>Conard, Mark W.</au><au>Williams, Randall E.</au><aucorp>Cardiovascular Outcomes Research Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2006-02-21</date><risdate>2006</risdate><volume>47</volume><issue>4</issue><spage>752</spage><epage>756</epage><pages>752-756</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract><![CDATA[Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death
Paul A. Heidenreich, John A. Spertus, Philip G. Jones, William S. Weintraub, John S. Rumsfeld, Saif S. Rathore, Eric D. Peterson, Frederick A. Masoudi, Harlan M. Krumholz, Edward P. Havranek, Mark W. Conard, Randall E. Williams, for the Cardiovascular Outcomes Research Consortium
To test the hypothesis that the Kansas City Cardiomyopathy Questionnaire (KCCQ) provides prognostic information independent of other clinical data, we evaluated 505 heart failure (HF) patients who had an ejection fraction <40%. At 12 months, among patients with a KCCQ score <25, 37% had been admitted for HF and 20% had died, compared with 7% (admissions) and 5% (death) of those with a KCCQ score ≥75 (p < 0.0001 for both comparisons). In sequential multivariable models adjusting for clinical variables, six-minute walk, and B-type natriuretic peptide levels, the KCCQ score remained significantly associated with survival free of HF hospitalization.
We tested the hypothesis that one health status measure, the Kansas City Cardiomyopathy Questionnaire (KCCQ), provides prognostic information independent of other clinical data in outpatients with heart failure (HF).
Health status measures are used to describe a patient’s clinical condition and have been shown to predict mortality in some populations. Their prognostic value may be particularly useful among patients with HF for identifying candidates for disease management in whom increased care may reduce hospitalizations and prevent death.
We evaluated 505 HF patients from 13 outpatient clinics who had an ejection fraction <40% using the KCCQ summary score. Proportional hazards regression was used to evaluate the association between the KCCQ summary score (range, 0 to 100; higher scores indicate better health status) and the primary outcome of death or HF admission, adjusting for baseline patient characteristics, 6-min walk distance, and B-type natriuretic peptide (BNP).
The mean age was 61 years, 76% of patients were male, 51% had an ischemic HF etiology, and 5% were New York Heart Association functional class IV. At 12 months, among the 9% of patients with a KCCQ score <25, 37% had been admitted for HF and 20% had died, compared with 7% (HF admissions) and 5% (death) of those with a KCCQ score ≥75 (33% of patients, p < 0.0001 for both comparisons). In sequential multivariable models adjusting for clinical variables, 6-min walk, and BNP levels, the KCCQ score remained significantly associated with survival free of HF hospitalization.
A low KCCQ score is an independent predictor of poor prognosis in outpatients with HF.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16487840</pmid><doi>10.1016/j.jacc.2005.11.021</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Age Ambulatory Care Biological and medical sciences Blood pressure Body mass index Cardiology Cardiology. Vascular system Cardiomyopathy Confidence intervals Diabetes Disease-Free Survival Drug therapy Female Health Status Heart Heart attacks Heart failure Heart Failure - complications Heart Failure - mortality Heart Failure - physiopathology Heart Failure - therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hospitalization Humans Hypertension Male Medical prognosis Medical sciences Middle Aged Mortality Older people Patients Peptides Prognosis Proportional Hazards Models Quality of Life Questionnaires Risk Factors Studies Surveys and Questionnaires Survival Rate |
| title | Health Status Identifies Heart Failure Outpatients at Risk for Hospitalization or Death |
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