Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin
The hydroethanolic extract of the leaves (HEL) and bark (HEB) obtained from Alchornea castaneaefolia (Euphorbiaceae) were investigated for their ability to prevent ulceration of the gastric mucosa in animal models. HEL (500 and 1000mg/kg) and HEB (1000mg/kg) significantly reduced the gastric injurie...
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| Veröffentlicht in: | Journal of ethnopharmacology 2006-03, Vol.104 (1-2), p.215-224 |
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| creator | Hiruma-Lima, Clélia Akiko Calvo, Tamara Roberta Rodrigues, Clenilson Martins Andrade, Fábio Donizete Pezzuto Vilegas, Wagner Brito, Alba Regina Monteiro Souza |
| description | The hydroethanolic extract of the leaves (HEL) and bark (HEB) obtained from Alchornea castaneaefolia (Euphorbiaceae) were investigated for their ability to prevent ulceration of the gastric mucosa in animal models. HEL (500 and 1000mg/kg) and HEB (1000mg/kg) significantly reduced the gastric injuries induced by the combination of HCl/ethanol and lowered the severity of gastric damage formation induced by indomethacin/bethanechol in mice. Further investigation showed that HEL also inhibited formation of ulcers in mice submitted to stress and pylorus ligature, but HEL did not modify gastric juice parameters in Shay mice. HEL was also effective in promoting the healing process in chronic gastric ulcer induced by acetic acid in rats. An enriched flavonoidic fraction (EFF at dose of 100mg/kg) obtained from HEL reduced gastric lesions induced by HCl/ethanol and indomethacin/bethanechol in mice. Although EFF did not modify the amount of free mucus production by gastric mucosa, it was able to increase prostaglandin production. When administered to rats submitted to ethanol-induced gastric lesions, EFF increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. Phytochemical investigation on HEL and EFF led to the isolation of flavonoids glycosides as the main compounds, thus suggesting that these substances may be involved in the observed antiulcer activity. |
| doi_str_mv | 10.1016/j.jep.2005.09.007 |
| format | Article |
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HEL (500 and 1000mg/kg) and HEB (1000mg/kg) significantly reduced the gastric injuries induced by the combination of HCl/ethanol and lowered the severity of gastric damage formation induced by indomethacin/bethanechol in mice. Further investigation showed that HEL also inhibited formation of ulcers in mice submitted to stress and pylorus ligature, but HEL did not modify gastric juice parameters in Shay mice. HEL was also effective in promoting the healing process in chronic gastric ulcer induced by acetic acid in rats. An enriched flavonoidic fraction (EFF at dose of 100mg/kg) obtained from HEL reduced gastric lesions induced by HCl/ethanol and indomethacin/bethanechol in mice. Although EFF did not modify the amount of free mucus production by gastric mucosa, it was able to increase prostaglandin production. When administered to rats submitted to ethanol-induced gastric lesions, EFF increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. Phytochemical investigation on HEL and EFF led to the isolation of flavonoids glycosides as the main compounds, thus suggesting that these substances may be involved in the observed antiulcer activity.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2005.09.007</identifier><identifier>PMID: 16253451</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Alchornea ; Alchornea castaneaefolia ; Animals ; anti-ulcer activity ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - pharmacology ; Anti-Ulcer Agents - therapeutic use ; Antiulcer activity ; bark ; Biological and medical sciences ; chemical constituents of plants ; Dose-Response Relationship, Drug ; Euphorbiaceae ; Flavonoids ; Gastrins - antagonists & inhibitors ; Gastrins - biosynthesis ; General pharmacology ; leaves ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Bark ; plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves ; Prostaglandins - biosynthesis ; Rats ; Rats, Wistar ; Somatostatin - biosynthesis ; Stomach Ulcer - drug therapy ; Stomach Ulcer - metabolism ; stomach ulcers</subject><ispartof>Journal of ethnopharmacology, 2006-03, Vol.104 (1-2), p.215-224</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-e2b5d6aca155a7ae20673dbf19ae86e49d274b7cfe3e134969366c3d49ea6e8f3</citedby><cites>FETCH-LOGICAL-c320t-e2b5d6aca155a7ae20673dbf19ae86e49d274b7cfe3e134969366c3d49ea6e8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2005.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17568782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16253451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiruma-Lima, Clélia Akiko</creatorcontrib><creatorcontrib>Calvo, Tamara Roberta</creatorcontrib><creatorcontrib>Rodrigues, Clenilson Martins</creatorcontrib><creatorcontrib>Andrade, Fábio Donizete Pezzuto</creatorcontrib><creatorcontrib>Vilegas, Wagner</creatorcontrib><creatorcontrib>Brito, Alba Regina Monteiro Souza</creatorcontrib><title>Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The hydroethanolic extract of the leaves (HEL) and bark (HEB) obtained from Alchornea castaneaefolia (Euphorbiaceae) were investigated for their ability to prevent ulceration of the gastric mucosa in animal models. HEL (500 and 1000mg/kg) and HEB (1000mg/kg) significantly reduced the gastric injuries induced by the combination of HCl/ethanol and lowered the severity of gastric damage formation induced by indomethacin/bethanechol in mice. Further investigation showed that HEL also inhibited formation of ulcers in mice submitted to stress and pylorus ligature, but HEL did not modify gastric juice parameters in Shay mice. HEL was also effective in promoting the healing process in chronic gastric ulcer induced by acetic acid in rats. An enriched flavonoidic fraction (EFF at dose of 100mg/kg) obtained from HEL reduced gastric lesions induced by HCl/ethanol and indomethacin/bethanechol in mice. Although EFF did not modify the amount of free mucus production by gastric mucosa, it was able to increase prostaglandin production. When administered to rats submitted to ethanol-induced gastric lesions, EFF increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. Phytochemical investigation on HEL and EFF led to the isolation of flavonoids glycosides as the main compounds, thus suggesting that these substances may be involved in the observed antiulcer activity.</description><subject>Alchornea</subject><subject>Alchornea castaneaefolia</subject><subject>Animals</subject><subject>anti-ulcer activity</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Antiulcer activity</subject><subject>bark</subject><subject>Biological and medical sciences</subject><subject>chemical constituents of plants</subject><subject>Dose-Response Relationship, Drug</subject><subject>Euphorbiaceae</subject><subject>Flavonoids</subject><subject>Gastrins - antagonists & inhibitors</subject><subject>Gastrins - biosynthesis</subject><subject>General pharmacology</subject><subject>leaves</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Bark</subject><subject>plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Prostaglandins - biosynthesis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Somatostatin - biosynthesis</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - metabolism</subject><subject>stomach ulcers</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi0EoqHwA7iAL3DqLv7YtXfhFFUtIFXiAD1bE-84dbSxg-1U6r_Hq0TqDcmSR_YzM68eQt5z1nLG1Zddu8NDKxjrWza2jOkXZMUHLRrda_mSrJjUQzPojl-QNznvWCV4x16TC65EL7uer8jDOhR_nC2muMXgLQVb_KMvTzQ6up7tQ0wBgVrIBWqBLs4evtIb59CWTGOgOe6hxPpdfLii2womHyiEiR7S8ryda-3DW_LKwZzx3fm-JPe3N3-ufzR3v77_vF7fNVYKVhoUm35SYIH3PWhAwZSW08bxEXBQ2I2T0N1GW4cSuexGNUqlrJy6EUHh4OQl-XyaW7f_PWIuZu-zxbmmwHjMRmlVj2YV5CfQ1pg5oTOH5PeQngxnZtFrdqbqNYtew0ZT5dWeD-fhx80ep-eOs88KfDoDkC3MLkGwPj9zuleDHkTlPp44B9HANlXm_rdgXC5bdD8uq76dCKyyHj0mk63HYHHyqao3U_T_CfoPDLejQw</recordid><startdate>20060308</startdate><enddate>20060308</enddate><creator>Hiruma-Lima, Clélia Akiko</creator><creator>Calvo, Tamara Roberta</creator><creator>Rodrigues, Clenilson Martins</creator><creator>Andrade, Fábio Donizete Pezzuto</creator><creator>Vilegas, Wagner</creator><creator>Brito, Alba Regina Monteiro Souza</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060308</creationdate><title>Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin</title><author>Hiruma-Lima, Clélia Akiko ; Calvo, Tamara Roberta ; Rodrigues, Clenilson Martins ; Andrade, Fábio Donizete Pezzuto ; Vilegas, Wagner ; Brito, Alba Regina Monteiro Souza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-e2b5d6aca155a7ae20673dbf19ae86e49d274b7cfe3e134969366c3d49ea6e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alchornea</topic><topic>Alchornea castaneaefolia</topic><topic>Animals</topic><topic>anti-ulcer activity</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Antiulcer activity</topic><topic>bark</topic><topic>Biological and medical sciences</topic><topic>chemical constituents of plants</topic><topic>Dose-Response Relationship, Drug</topic><topic>Euphorbiaceae</topic><topic>Flavonoids</topic><topic>Gastrins - antagonists & inhibitors</topic><topic>Gastrins - biosynthesis</topic><topic>General pharmacology</topic><topic>leaves</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Bark</topic><topic>plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Prostaglandins - biosynthesis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Somatostatin - biosynthesis</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - metabolism</topic><topic>stomach ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiruma-Lima, Clélia Akiko</creatorcontrib><creatorcontrib>Calvo, Tamara Roberta</creatorcontrib><creatorcontrib>Rodrigues, Clenilson Martins</creatorcontrib><creatorcontrib>Andrade, Fábio Donizete Pezzuto</creatorcontrib><creatorcontrib>Vilegas, Wagner</creatorcontrib><creatorcontrib>Brito, Alba Regina Monteiro Souza</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiruma-Lima, Clélia Akiko</au><au>Calvo, Tamara Roberta</au><au>Rodrigues, Clenilson Martins</au><au>Andrade, Fábio Donizete Pezzuto</au><au>Vilegas, Wagner</au><au>Brito, Alba Regina Monteiro Souza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2006-03-08</date><risdate>2006</risdate><volume>104</volume><issue>1-2</issue><spage>215</spage><epage>224</epage><pages>215-224</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The hydroethanolic extract of the leaves (HEL) and bark (HEB) obtained from Alchornea castaneaefolia (Euphorbiaceae) were investigated for their ability to prevent ulceration of the gastric mucosa in animal models. HEL (500 and 1000mg/kg) and HEB (1000mg/kg) significantly reduced the gastric injuries induced by the combination of HCl/ethanol and lowered the severity of gastric damage formation induced by indomethacin/bethanechol in mice. Further investigation showed that HEL also inhibited formation of ulcers in mice submitted to stress and pylorus ligature, but HEL did not modify gastric juice parameters in Shay mice. HEL was also effective in promoting the healing process in chronic gastric ulcer induced by acetic acid in rats. An enriched flavonoidic fraction (EFF at dose of 100mg/kg) obtained from HEL reduced gastric lesions induced by HCl/ethanol and indomethacin/bethanechol in mice. Although EFF did not modify the amount of free mucus production by gastric mucosa, it was able to increase prostaglandin production. When administered to rats submitted to ethanol-induced gastric lesions, EFF increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. Phytochemical investigation on HEL and EFF led to the isolation of flavonoids glycosides as the main compounds, thus suggesting that these substances may be involved in the observed antiulcer activity.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16253451</pmid><doi>10.1016/j.jep.2005.09.007</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0378-8741 |
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| issn | 0378-8741 1872-7573 |
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| subjects | Alchornea Alchornea castaneaefolia Animals anti-ulcer activity Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use Antiulcer activity bark Biological and medical sciences chemical constituents of plants Dose-Response Relationship, Drug Euphorbiaceae Flavonoids Gastrins - antagonists & inhibitors Gastrins - biosynthesis General pharmacology leaves Male Medical sciences medicinal plants medicinal properties Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Prostaglandins - biosynthesis Rats Rats, Wistar Somatostatin - biosynthesis Stomach Ulcer - drug therapy Stomach Ulcer - metabolism stomach ulcers |
| title | Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin |
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