Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases
The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive...
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| Veröffentlicht in: | International journal of surgical pathology 2009-10, Vol.17 (5), p.384-389 |
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| container_title | International journal of surgical pathology |
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| creator | Koreishi, Aashiyana F. Saenz, Adam J. Fleming, Stephen E. Teruya-Feldstein, Julie |
| description | The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy. |
| doi_str_mv | 10.1177/1066896909342568 |
| format | Article |
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All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.</description><subject>Aged</subject><subject>Biomarkers - metabolism</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Hemangioma - metabolism</subject><subject>Hemangioma - pathology</subject><subject>Hemangioma - surgery</subject><subject>Humans</subject><subject>Immunoglobulin G - metabolism</subject><subject>Middle Aged</subject><subject>Plasma Cells - metabolism</subject><subject>Plasma Cells - pathology</subject><subject>Positron-Emission Tomography</subject><subject>Radiography</subject><subject>Sclerosis</subject><subject>Spleen - blood supply</subject><subject>Spleen - diagnostic imaging</subject><subject>Splenectomy</subject><subject>Splenic Neoplasms - metabolism</subject><subject>Splenic Neoplasms - pathology</subject><subject>Splenic Neoplasms - surgery</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UE1LxDAQDaK468fdk-QkeqgmbZo03sriFywruCseS5pO1i5tU5P24L83yy4IgjAww3tvHjMPoQtKbikV4o4SzjPJJZEJi1OeHaAplYxEMePpYZgDHW35CTrxfkMIiXlMj9GESs65ZGKKPpa6AWd93a1x3q1r26rB1hVe2GpslMMrpzpvrAtwbTt8vcwXqxtsDR4-AS_7BqC7xzl-g966YYsneKY8-DN0ZFTj4XzfT9H748Nq9hzNX59eZvk80ozQIQIJZZykmcioAaplmvGEmiycGQOVsqo0y3hqSsFFWsWlliIxJVeECgpMxTo5RVc7397ZrxH8ULS119A0qgM7-oILHoplQUh2Qh2-9Q5M0bu6Ve67oKTYhln8DTOsXO69x7KF6ndhn14QRDuBV2soNnZ0Xfj1f8Mf-1l6XA</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Koreishi, Aashiyana F.</creator><creator>Saenz, Adam J.</creator><creator>Fleming, Stephen E.</creator><creator>Teruya-Feldstein, Julie</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases</title><author>Koreishi, Aashiyana F. ; Saenz, Adam J. ; Fleming, Stephen E. ; Teruya-Feldstein, Julie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-e9eb2358781fe1c958631f82622e199ddc4865fb7675d2bc973fb6a0171e4a2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biomarkers - metabolism</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Hemangioma - metabolism</topic><topic>Hemangioma - pathology</topic><topic>Hemangioma - surgery</topic><topic>Humans</topic><topic>Immunoglobulin G - metabolism</topic><topic>Middle Aged</topic><topic>Plasma Cells - metabolism</topic><topic>Plasma Cells - pathology</topic><topic>Positron-Emission Tomography</topic><topic>Radiography</topic><topic>Sclerosis</topic><topic>Spleen - blood supply</topic><topic>Spleen - diagnostic imaging</topic><topic>Splenectomy</topic><topic>Splenic Neoplasms - metabolism</topic><topic>Splenic Neoplasms - pathology</topic><topic>Splenic Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koreishi, Aashiyana F.</creatorcontrib><creatorcontrib>Saenz, Adam J.</creatorcontrib><creatorcontrib>Fleming, Stephen E.</creatorcontrib><creatorcontrib>Teruya-Feldstein, Julie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koreishi, Aashiyana F.</au><au>Saenz, Adam J.</au><au>Fleming, Stephen E.</au><au>Teruya-Feldstein, Julie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>17</volume><issue>5</issue><spage>384</spage><epage>389</epage><pages>384-389</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>19666947</pmid><doi>10.1177/1066896909342568</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of surgical pathology, 2009-10, Vol.17 (5), p.384-389 |
| issn | 1066-8969 1940-2465 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Aged Biomarkers - metabolism Disease-Free Survival Female Hemangioma - metabolism Hemangioma - pathology Hemangioma - surgery Humans Immunoglobulin G - metabolism Middle Aged Plasma Cells - metabolism Plasma Cells - pathology Positron-Emission Tomography Radiography Sclerosis Spleen - blood supply Spleen - diagnostic imaging Splenectomy Splenic Neoplasms - metabolism Splenic Neoplasms - pathology Splenic Neoplasms - surgery |
| title | Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases |
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