The clinical value of parasternal sentinel node biopsy in breast cancer
Lymphoscintigraphy (LS) with sentinel node (SN) biopsy is proposed to provide a feasible method to complete lymphatic staging in breast cancer. The aim of this study was to evaluate the clinical value of parasternal SN biopsy. A total of 984 consecutive patients with clinical stage T1/2N0 invasive b...
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| Veröffentlicht in: | Annals of surgical oncology 2006-03, Vol.13 (3), p.321-326 |
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| container_title | Annals of surgical oncology |
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| creator | Leidenius, Marjut Hannele Kristiina Krogerus, Leena Anneli Toivonen, Terttu Sinikka Leppänen, Esa Antero von Smitten, Karl Albert Johan |
| description | Lymphoscintigraphy (LS) with sentinel node (SN) biopsy is proposed to provide a feasible method to complete lymphatic staging in breast cancer. The aim of this study was to evaluate the clinical value of parasternal SN biopsy.
A total of 984 consecutive patients with clinical stage T1/2N0 invasive breast cancer who underwent LS and SN biopsy were included in the study. A prospectively collected database was used. An intratumoral injection of 50 to 145 MBq of (99m)Tc-labeled human albumin colloid (Nanocoll) was used for preoperative LS.
LS showed the axillary SN in 844 (86%) cases and the parasternal SN in 138 (14%) cases. The median number of visualized parasternal SN was 2 (range, 1-6). Visualization of the parasternal SN was more common in patients with mediocentral tumors (81 of 399; 20%) and in patients with lateral tumors (56 of 585; 10%; P < .0001). Parasternal SNs were visualized more often, in 100 (17%) of 584 patients without axillary metastases compared with 38 (10%) of 400 patients with metastatic axillary nodes (P = .0006). Parasternal SNs were harvested successfully in 121 (88%) patients with visualization of those nodes. Parasternal SN metastases were detected in 18 patients, with a median of 1 metastasis (range, 1-4 metastases). Eight of these 18 patients were axillary node negative.
Parasternal SN biopsy results in upstaging in 2% of all breast cancer patients who undergo SN biopsy. The clinical value of the procedure seems insignificant, although it may influence the adjuvant treatment regimen in some patients. |
| doi_str_mv | 10.1245/ASO.2006.02.022 |
| format | Article |
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A total of 984 consecutive patients with clinical stage T1/2N0 invasive breast cancer who underwent LS and SN biopsy were included in the study. A prospectively collected database was used. An intratumoral injection of 50 to 145 MBq of (99m)Tc-labeled human albumin colloid (Nanocoll) was used for preoperative LS.
LS showed the axillary SN in 844 (86%) cases and the parasternal SN in 138 (14%) cases. The median number of visualized parasternal SN was 2 (range, 1-6). Visualization of the parasternal SN was more common in patients with mediocentral tumors (81 of 399; 20%) and in patients with lateral tumors (56 of 585; 10%; P < .0001). Parasternal SNs were visualized more often, in 100 (17%) of 584 patients without axillary metastases compared with 38 (10%) of 400 patients with metastatic axillary nodes (P = .0006). Parasternal SNs were harvested successfully in 121 (88%) patients with visualization of those nodes. Parasternal SN metastases were detected in 18 patients, with a median of 1 metastasis (range, 1-4 metastases). Eight of these 18 patients were axillary node negative.
Parasternal SN biopsy results in upstaging in 2% of all breast cancer patients who undergo SN biopsy. The clinical value of the procedure seems insignificant, although it may influence the adjuvant treatment regimen in some patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/ASO.2006.02.022</identifier><identifier>PMID: 16485152</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Chemotherapy, Adjuvant ; Child ; Child, Preschool ; Databases, Factual ; Decision Making ; Female ; Humans ; Lymphatic Metastasis - diagnostic imaging ; Middle Aged ; Neoplasm Staging - methods ; Prospective Studies ; Radionuclide Imaging ; Radiotherapy, Adjuvant ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy ; Technetium Tc 99m Aggregated Albumin</subject><ispartof>Annals of surgical oncology, 2006-03, Vol.13 (3), p.321-326</ispartof><rights>The Society of Surgical Oncology, Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-98779eada086eb4092198ac9700c9247fb09a45f511c6a18317ce981f9c4cf9f3</citedby><cites>FETCH-LOGICAL-c322t-98779eada086eb4092198ac9700c9247fb09a45f511c6a18317ce981f9c4cf9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16485152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leidenius, Marjut Hannele Kristiina</creatorcontrib><creatorcontrib>Krogerus, Leena Anneli</creatorcontrib><creatorcontrib>Toivonen, Terttu Sinikka</creatorcontrib><creatorcontrib>Leppänen, Esa Antero</creatorcontrib><creatorcontrib>von Smitten, Karl Albert Johan</creatorcontrib><title>The clinical value of parasternal sentinel node biopsy in breast cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><description>Lymphoscintigraphy (LS) with sentinel node (SN) biopsy is proposed to provide a feasible method to complete lymphatic staging in breast cancer. The aim of this study was to evaluate the clinical value of parasternal SN biopsy.
A total of 984 consecutive patients with clinical stage T1/2N0 invasive breast cancer who underwent LS and SN biopsy were included in the study. A prospectively collected database was used. An intratumoral injection of 50 to 145 MBq of (99m)Tc-labeled human albumin colloid (Nanocoll) was used for preoperative LS.
LS showed the axillary SN in 844 (86%) cases and the parasternal SN in 138 (14%) cases. The median number of visualized parasternal SN was 2 (range, 1-6). Visualization of the parasternal SN was more common in patients with mediocentral tumors (81 of 399; 20%) and in patients with lateral tumors (56 of 585; 10%; P < .0001). Parasternal SNs were visualized more often, in 100 (17%) of 584 patients without axillary metastases compared with 38 (10%) of 400 patients with metastatic axillary nodes (P = .0006). Parasternal SNs were harvested successfully in 121 (88%) patients with visualization of those nodes. Parasternal SN metastases were detected in 18 patients, with a median of 1 metastasis (range, 1-4 metastases). Eight of these 18 patients were axillary node negative.
Parasternal SN biopsy results in upstaging in 2% of all breast cancer patients who undergo SN biopsy. The clinical value of the procedure seems insignificant, although it may influence the adjuvant treatment regimen in some patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Databases, Factual</subject><subject>Decision Making</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>Prospective Studies</subject><subject>Radionuclide Imaging</subject><subject>Radiotherapy, Adjuvant</subject><subject>Sensitivity and Specificity</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Technetium Tc 99m Aggregated Albumin</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEFLAzEQRoMoVqtnbxI8eNs2mU2yybEUrUKhB-s5ZNNZ3LLdrcmu0H9vSguC8MEMw5uBeYQ8cDbhIOR09rGaAGNqwiAFLsgNl7nIhNL8MvVM6cyAkiNyG-OWMV7kTF6TEVdCSy7hhizWX0h9U7e1dw39cc2AtKvo3gUXewxtGkZs-7rFhrbdBmlZd_t4oHVLy4CJod61HsMduapcE_H-XMfk8_VlPX_LlqvF-3y2zHwO0GdGF4VBt3FMKywFM8CNdt4UjHkDoqhKZpyQleTcK8d1zguPRvPKeOErU-Vj8ny6uw_d94Cxt7s6emwa12I3RKsKpRQwlcCnf-C2G47_RAtQ5BokmARNT5APXYwBK7sP9c6Fg-XMHgXbJNgeBVsGKZA2Hs9nh3KHmz_-bDT_BWpsdL0</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Leidenius, Marjut Hannele Kristiina</creator><creator>Krogerus, Leena Anneli</creator><creator>Toivonen, Terttu Sinikka</creator><creator>Leppänen, Esa Antero</creator><creator>von Smitten, Karl Albert Johan</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>The clinical value of parasternal sentinel node biopsy in breast cancer</title><author>Leidenius, Marjut Hannele Kristiina ; 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The aim of this study was to evaluate the clinical value of parasternal SN biopsy.
A total of 984 consecutive patients with clinical stage T1/2N0 invasive breast cancer who underwent LS and SN biopsy were included in the study. A prospectively collected database was used. An intratumoral injection of 50 to 145 MBq of (99m)Tc-labeled human albumin colloid (Nanocoll) was used for preoperative LS.
LS showed the axillary SN in 844 (86%) cases and the parasternal SN in 138 (14%) cases. The median number of visualized parasternal SN was 2 (range, 1-6). Visualization of the parasternal SN was more common in patients with mediocentral tumors (81 of 399; 20%) and in patients with lateral tumors (56 of 585; 10%; P < .0001). Parasternal SNs were visualized more often, in 100 (17%) of 584 patients without axillary metastases compared with 38 (10%) of 400 patients with metastatic axillary nodes (P = .0006). Parasternal SNs were harvested successfully in 121 (88%) patients with visualization of those nodes. Parasternal SN metastases were detected in 18 patients, with a median of 1 metastasis (range, 1-4 metastases). Eight of these 18 patients were axillary node negative.
Parasternal SN biopsy results in upstaging in 2% of all breast cancer patients who undergo SN biopsy. The clinical value of the procedure seems insignificant, although it may influence the adjuvant treatment regimen in some patients.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16485152</pmid><doi>10.1245/ASO.2006.02.022</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2006-03, Vol.13 (3), p.321-326 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Breast Neoplasms - therapy Chemotherapy, Adjuvant Child Child, Preschool Databases, Factual Decision Making Female Humans Lymphatic Metastasis - diagnostic imaging Middle Aged Neoplasm Staging - methods Prospective Studies Radionuclide Imaging Radiotherapy, Adjuvant Sensitivity and Specificity Sentinel Lymph Node Biopsy Technetium Tc 99m Aggregated Albumin |
| title | The clinical value of parasternal sentinel node biopsy in breast cancer |
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