Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men
Objectives: To determine the prevalence and risk factors for anal human papillomavirus (HPV) infection in community-based cohorts of homosexual men in Sydney, Australia. Methods: A cross-sectional study in consecutively presenting participants in the positive Health and Health in Men cohorts in 2005...
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| Veröffentlicht in: | Sexually transmitted infections 2009-09, Vol.85 (5), p.330-335 |
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| creator | Vajdic, C M van Leeuwen, M T Jin, F Prestage, G Medley, G Hillman, R J Stevens, M P Botes, L P Zablotska, I Tabrizi, S N Grulich, A E |
| description | Objectives: To determine the prevalence and risk factors for anal human papillomavirus (HPV) infection in community-based cohorts of homosexual men in Sydney, Australia. Methods: A cross-sectional study in consecutively presenting participants in the positive Health and Health in Men cohorts in 2005. HPV testing was performed on anal PreservCyt specimens collected from 316 homosexual men (193 HIV-negative, 123 HIV-positive) using the Digene Hybrid Capture 2 (HC-2) assay for detection of low-risk (LR) and high-risk (HR) genotypes. HPV genotype testing was also performed on a subset of 133 men (93 HIV-negative, 36 HIV-positive) using Roche Linear Array (LA) assay. Results: HC-2 detected HPV infection in 79% of men (LR 55%, HR 69%). HIV-positive men were more likely than HIV-negative men to have LR-HPV (OR 3.5, 95% CI 2.1 to 5.7) and HR-HPV (OR 5.5, 95% CI 3.0 to 10.2). LA detected HPV infection in 95% of men (LR 85%, HR 77%). HIV-positive men had a mean of 7.1 HPV types compared to 4.2 in HIV-negative men; the difference was significant for both LR-HPV (p |
| doi_str_mv | 10.1136/sti.2008.034744 |
| format | Article |
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Methods: A cross-sectional study in consecutively presenting participants in the positive Health and Health in Men cohorts in 2005. HPV testing was performed on anal PreservCyt specimens collected from 316 homosexual men (193 HIV-negative, 123 HIV-positive) using the Digene Hybrid Capture 2 (HC-2) assay for detection of low-risk (LR) and high-risk (HR) genotypes. HPV genotype testing was also performed on a subset of 133 men (93 HIV-negative, 36 HIV-positive) using Roche Linear Array (LA) assay. Results: HC-2 detected HPV infection in 79% of men (LR 55%, HR 69%). HIV-positive men were more likely than HIV-negative men to have LR-HPV (OR 3.5, 95% CI 2.1 to 5.7) and HR-HPV (OR 5.5, 95% CI 3.0 to 10.2). LA detected HPV infection in 95% of men (LR 85%, HR 77%). HIV-positive men had a mean of 7.1 HPV types compared to 4.2 in HIV-negative men; the difference was significant for both LR-HPV (p<0.001) and HR-HPV (p<0.001). HPV-16 was detected in 36% of HIV-positive and 27% of HIV-negative men. There was no consistent trend in HPV prevalence with increasing age. HR-HPV detection was associated with anal bleeding for HIV-positive men and anal warts for HIV-negative men. Conclusions: Anal HPV infection was nearly universal in this community-based sample of homosexual men. A wide variety of HPV genotypes were detected, and co-infection with multiple genotypes was common. Anal HPV infection is more prevalent and more diverse in HIV-positive than HIV-negative homosexual men.</description><identifier>ISSN: 1368-4973</identifier><identifier>EISSN: 1472-3263</identifier><identifier>DOI: 10.1136/sti.2008.034744</identifier><identifier>PMID: 19342375</identifier><language>eng</language><publisher>London: BMJ Publishing Group</publisher><subject>Adult ; Anal Canal - virology ; Anus Diseases - epidemiology ; Anus Diseases - virology ; Behavior ; Biological and medical sciences ; Cervical cancer ; Confidence intervals ; Cross-Sectional Studies ; Epidemiology. Vaccinations ; General aspects ; Genotype ; Genotype & phenotype ; HIV ; HIV Infections - epidemiology ; Homosexuality, Male ; Human immunodeficiency virus ; Human infectious diseases. Experimental studies and models ; Human papillomavirus ; Humans ; Infections ; Infectious diseases ; Male ; Medical sciences ; Mens health ; Middle Aged ; New South Wales - epidemiology ; Papillomaviridae - genetics ; Papillomavirus Infections - epidemiology ; Population ; Prevalence ; Risk Factors ; Variables</subject><ispartof>Sexually transmitted infections, 2009-09, Vol.85 (5), p.330-335</ispartof><rights>2009 BMJ Publishing Group</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2009 2009 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b388t-ba4a188d8f5d2d50a1ffc8d2e433d81e7b45d1f2948e64e0562d453600a088693</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://sti.bmj.com/content/85/5/330.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://sti.bmj.com/content/85/5/330.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21722546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19342375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vajdic, C M</creatorcontrib><creatorcontrib>van Leeuwen, M T</creatorcontrib><creatorcontrib>Jin, F</creatorcontrib><creatorcontrib>Prestage, G</creatorcontrib><creatorcontrib>Medley, G</creatorcontrib><creatorcontrib>Hillman, R J</creatorcontrib><creatorcontrib>Stevens, M P</creatorcontrib><creatorcontrib>Botes, L P</creatorcontrib><creatorcontrib>Zablotska, I</creatorcontrib><creatorcontrib>Tabrizi, S N</creatorcontrib><creatorcontrib>Grulich, A E</creatorcontrib><title>Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men</title><title>Sexually transmitted infections</title><addtitle>Sex Transm Infect</addtitle><description>Objectives: To determine the prevalence and risk factors for anal human papillomavirus (HPV) infection in community-based cohorts of homosexual men in Sydney, Australia. Methods: A cross-sectional study in consecutively presenting participants in the positive Health and Health in Men cohorts in 2005. HPV testing was performed on anal PreservCyt specimens collected from 316 homosexual men (193 HIV-negative, 123 HIV-positive) using the Digene Hybrid Capture 2 (HC-2) assay for detection of low-risk (LR) and high-risk (HR) genotypes. HPV genotype testing was also performed on a subset of 133 men (93 HIV-negative, 36 HIV-positive) using Roche Linear Array (LA) assay. Results: HC-2 detected HPV infection in 79% of men (LR 55%, HR 69%). HIV-positive men were more likely than HIV-negative men to have LR-HPV (OR 3.5, 95% CI 2.1 to 5.7) and HR-HPV (OR 5.5, 95% CI 3.0 to 10.2). LA detected HPV infection in 95% of men (LR 85%, HR 77%). HIV-positive men had a mean of 7.1 HPV types compared to 4.2 in HIV-negative men; the difference was significant for both LR-HPV (p<0.001) and HR-HPV (p<0.001). HPV-16 was detected in 36% of HIV-positive and 27% of HIV-negative men. There was no consistent trend in HPV prevalence with increasing age. HR-HPV detection was associated with anal bleeding for HIV-positive men and anal warts for HIV-negative men. Conclusions: Anal HPV infection was nearly universal in this community-based sample of homosexual men. A wide variety of HPV genotypes were detected, and co-infection with multiple genotypes was common. Anal HPV infection is more prevalent and more diverse in HIV-positive than HIV-negative homosexual men.</description><subject>Adult</subject><subject>Anal Canal - virology</subject><subject>Anus Diseases - epidemiology</subject><subject>Anus Diseases - virology</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Cervical cancer</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology. Vaccinations</subject><subject>General aspects</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>HIV</subject><subject>HIV Infections - epidemiology</subject><subject>Homosexuality, Male</subject><subject>Human immunodeficiency virus</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>New South Wales - epidemiology</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Population</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Variables</subject><issn>1368-4973</issn><issn>1472-3263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0cuLFDEQB-BGFPehZ28SEPcg9GzeSR-XxRcseNFzSHcqbsZO0ibdi_Pfm2UGBS-eElJfqqB-XfeK4B0hTF7XNewoxnqHGVecP-nOCVe0Z1Syp-3OpO75oNhZd1HrHmMslRied2dkYJwyJc67HzfJzuh-izahxS5hnnO0D6FsFX2HlNfDAsiFByg1rAdkk0NT7kPyMK0hJxQSsu0lxi21ej_aCg5VG5cZUPboPsdc4dfWRkRIL7pn3s4VXp7Oy-7bh_dfbz_1d18-fr69uetHpvXamnBLtHbaC0edwJZ4P2lHgTPmNAE1cuGIpwPXIDlgIanjgkmMLdZaDuyyuzr2XUr-uUFdTQx1gnm2CfJWjVRSCslYg2_-gfu8lbaQaojSpDkteFPXRzWVXGsBb5YSoi0HQ7B5TMG0FMxjCuaYQvvx-tR3GyO4v_609gbenoCtk519sWkK9Y-jRFEquGzu3dGNcf_fqb8Btgidlg</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Vajdic, C M</creator><creator>van Leeuwen, M T</creator><creator>Jin, F</creator><creator>Prestage, G</creator><creator>Medley, G</creator><creator>Hillman, R J</creator><creator>Stevens, M P</creator><creator>Botes, L P</creator><creator>Zablotska, I</creator><creator>Tabrizi, S N</creator><creator>Grulich, A E</creator><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men</title><author>Vajdic, C M ; van Leeuwen, M T ; Jin, F ; Prestage, G ; Medley, G ; Hillman, R J ; Stevens, M P ; Botes, L P ; Zablotska, I ; Tabrizi, S N ; Grulich, A E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b388t-ba4a188d8f5d2d50a1ffc8d2e433d81e7b45d1f2948e64e0562d453600a088693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Anal Canal - virology</topic><topic>Anus Diseases - epidemiology</topic><topic>Anus Diseases - virology</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Cervical cancer</topic><topic>Confidence intervals</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology. Vaccinations</topic><topic>General aspects</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>Homosexuality, Male</topic><topic>Human immunodeficiency virus</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>New South Wales - epidemiology</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Population</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vajdic, C M</creatorcontrib><creatorcontrib>van Leeuwen, M T</creatorcontrib><creatorcontrib>Jin, F</creatorcontrib><creatorcontrib>Prestage, G</creatorcontrib><creatorcontrib>Medley, G</creatorcontrib><creatorcontrib>Hillman, R J</creatorcontrib><creatorcontrib>Stevens, M P</creatorcontrib><creatorcontrib>Botes, L P</creatorcontrib><creatorcontrib>Zablotska, I</creatorcontrib><creatorcontrib>Tabrizi, S N</creatorcontrib><creatorcontrib>Grulich, A E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sexually transmitted infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vajdic, C M</au><au>van Leeuwen, M T</au><au>Jin, F</au><au>Prestage, G</au><au>Medley, G</au><au>Hillman, R J</au><au>Stevens, M P</au><au>Botes, L P</au><au>Zablotska, I</au><au>Tabrizi, S N</au><au>Grulich, A E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men</atitle><jtitle>Sexually transmitted infections</jtitle><addtitle>Sex Transm Infect</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>85</volume><issue>5</issue><spage>330</spage><epage>335</epage><pages>330-335</pages><issn>1368-4973</issn><eissn>1472-3263</eissn><abstract>Objectives: To determine the prevalence and risk factors for anal human papillomavirus (HPV) infection in community-based cohorts of homosexual men in Sydney, Australia. Methods: A cross-sectional study in consecutively presenting participants in the positive Health and Health in Men cohorts in 2005. HPV testing was performed on anal PreservCyt specimens collected from 316 homosexual men (193 HIV-negative, 123 HIV-positive) using the Digene Hybrid Capture 2 (HC-2) assay for detection of low-risk (LR) and high-risk (HR) genotypes. HPV genotype testing was also performed on a subset of 133 men (93 HIV-negative, 36 HIV-positive) using Roche Linear Array (LA) assay. Results: HC-2 detected HPV infection in 79% of men (LR 55%, HR 69%). HIV-positive men were more likely than HIV-negative men to have LR-HPV (OR 3.5, 95% CI 2.1 to 5.7) and HR-HPV (OR 5.5, 95% CI 3.0 to 10.2). LA detected HPV infection in 95% of men (LR 85%, HR 77%). HIV-positive men had a mean of 7.1 HPV types compared to 4.2 in HIV-negative men; the difference was significant for both LR-HPV (p<0.001) and HR-HPV (p<0.001). HPV-16 was detected in 36% of HIV-positive and 27% of HIV-negative men. There was no consistent trend in HPV prevalence with increasing age. HR-HPV detection was associated with anal bleeding for HIV-positive men and anal warts for HIV-negative men. Conclusions: Anal HPV infection was nearly universal in this community-based sample of homosexual men. A wide variety of HPV genotypes were detected, and co-infection with multiple genotypes was common. Anal HPV infection is more prevalent and more diverse in HIV-positive than HIV-negative homosexual men.</abstract><cop>London</cop><pub>BMJ Publishing Group</pub><pmid>19342375</pmid><doi>10.1136/sti.2008.034744</doi><tpages>6</tpages></addata></record> |
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| ispartof | Sexually transmitted infections, 2009-09, Vol.85 (5), p.330-335 |
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| subjects | Adult Anal Canal - virology Anus Diseases - epidemiology Anus Diseases - virology Behavior Biological and medical sciences Cervical cancer Confidence intervals Cross-Sectional Studies Epidemiology. Vaccinations General aspects Genotype Genotype & phenotype HIV HIV Infections - epidemiology Homosexuality, Male Human immunodeficiency virus Human infectious diseases. Experimental studies and models Human papillomavirus Humans Infections Infectious diseases Male Medical sciences Mens health Middle Aged New South Wales - epidemiology Papillomaviridae - genetics Papillomavirus Infections - epidemiology Population Prevalence Risk Factors Variables |
| title | Anal human papillomavirus genotype diversity and co-infection in a community-based sample of homosexual men |
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