A membrane-permeable peptide containing the last 21 residues of the G alpha(s) carboxyl terminus inhibits G(s)-coupled receptor signaling in intact cells: correlations between peptide structure and biological activity

Cell-penetrating peptides are able to transport covalently attached cargoes such as peptide or polypeptide fragments of endogenous proteins across cell membranes. Taking advantage of the cell-penetrating properties of the 16-residue fragment penetratin, we synthesized a chimeric peptide that possess...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 2006-03, Vol.69 (3), p.727-736
Hauptverfasser:	D'Ursi, Anna Maria, Giusti, Laura, Albrizio, Stefania, Porchia, Francesca, Esposito, Cinzia, Caliendo, Gabriella, Gargini, Claudia, Novellino, Ettore, Lucacchini, Antonio, Rovero, Paolo, Mazzoni, Maria Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine-5'-(N-ethylcarboxamide) - antagonists & inhibitors Animals Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Membrane - metabolism Cyclic AMP - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism GTP-Binding Protein alpha Subunits, Gs - antagonists & inhibitors GTP-Binding Protein alpha Subunits, Gs - chemistry GTP-Binding Protein alpha Subunits, Gs - metabolism Humans Isoproterenol - pharmacology Magnetic Resonance Spectroscopy Membrane Proteins - chemistry Membrane Proteins - metabolism Membrane Proteins - pharmacology PC12 Cells Peptide Fragments - chemistry Peptide Fragments - metabolism Peptide Fragments - pharmacology Permeability Protein Conformation Proteins Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Signal Transduction - drug effects Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!