Atherosclerosis in Mice Is Not Affected by a Reduction in Tissue Factor Expression

OBJECTIVE—To determine whether tissue factor (TF) contributes to the progression of atherosclerotic lesions in mice. METHODS AND RESULTS—We determined the effect of a 50% reduction of TF levels in all cells on atherosclerosis in apolipoprotein E-deficient (apoE) mice. No differences were observed in...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2006-03, Vol.26 (3), p.555-562
Hauptverfasser:	Tilley, Rachel E, Pedersen, Brian, Pawlinski, Rafal, Sato, Yuichiro, Erlich, Jonathan H, Shen, Yuechun, Day, Sharlene, Huang, Ying, Eitzman, Daniel T, Boisvert, William A, Curtiss, Linda K, Fay, William P, Mackman, Nigel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Aorta - physiology Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Bone Marrow Transplantation Cardiology. Vascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug toxicity and drugs side effects treatment Gene Expression Heart Hematopoietic Stem Cells - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Mutant Strains Pharmacology. Drug treatments Receptors, LDL - genetics Thromboplastin - genetics Thromboplastin - metabolism Toxicity: cardiovascular system
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