Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway

The Birt–Hogg–Dubé gene (BHD) encodes the tumor suppressor protein folliculin (FLCN). The function of FLCN has recently been implicated in the regulation of rapamycin-sensitive mTOR complex (mTORC1). Reciprocally, the mTORC1-dependent phosphorylation of FLCN was reported. However, precise mechanism...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-11, Vol.389 (1), p.16-21
Hauptverfasser:	Piao, Xianghua, Kobayashi, Toshiyuki, Wang, Lu, Shiono, Masatoshi, Takagi, Yumiko, Sun, Guodong, Abe, Masaaki, Hagiwara, Yoshiaki, Zhang, Danqing, Okimoto, Kazuo, Kouchi, Mami, Matsumoto, Izumi, Hino, Okio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution AMPK Animals BHD Cell Line, Tumor FLCN Monomeric GTP-Binding Proteins - metabolism mTOR Neuropeptides - metabolism Phosphorylation Protein Kinases - metabolism Proteins - genetics Proteins - metabolism Ras Homolog Enriched in Brain Protein Rats Rheb S6K Serine - genetics Serine - metabolism TOR Serine-Threonine Kinases Trans-Activators Transcription Factors - metabolism Tsc2 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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