Determination of the surface free energy of crystalline and amorphous lactose by atomic force microscopy adhesion measurement

This study was conducted to accurately measure the dispersive surface free energy of lactose solids in ordered and disordered states. Atomic force microscopy (AFM) was used to determine the contact adhesion force between an AFM tip and lactose under low humidity (ca. 1% RH). The geometry of the tip...

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Veröffentlicht in:Pharmaceutical research 2006-02, Vol.23 (2), p.401-407
Hauptverfasser: JIANXIN ZHANG, EBBENS, Stephen, XINYONG CHEN, ZHENG JIN, LUK, Shen, MADDEN, Claire, PATEL, Nikin, ROBERTS, Clive J
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Sprache:eng
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