Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells: The crucial role of PTEN

Objective This study aimed to investigate the mechanisms of action of WEB-2170, an inverse agonist of platelet-activating factor receptor, capable of inducing apoptosis in human acute myelogenous leukemia (AML) cells. Material and Methods Gene expression profiling followed by cytofluorimetric, morph...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental hematology 2009-10, Vol.37 (10), p.1176-1185.e21
Hauptverfasser:	Cellai, Cristina, Laurenzana, Anna, Bianchi, Elisa, Sdelci, Sara, Manfredini, Rossella, Vannucchi, Alessandro M, Caporale, Roberto, Balliu, Manjola, Mannelli, Francesco, Ferrari, Sergio, Bosi, Alberto, Miniati, Debora, Cocco, Pier L, Veronneau, Steeve, Stankova, Jana, Paoletti, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Advanced Basic Science Aged Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Azepines - pharmacology Cell Line, Tumor - drug effects Female Gene Expression Profiling Gene Expression Regulation, Leukemic - drug effects Gene Expression Regulation, Leukemic - physiology Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid - pathology Male Middle Aged Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Phosphorylation - drug effects Polymerase Chain Reaction Protein Processing, Post-Translational - drug effects Protein Transport - drug effects PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - biosynthesis PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - physiology Resting Phase, Cell Cycle - drug effects RNA Interference RNA, Small Interfering - pharmacology Triazoles - pharmacology Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!