Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation

Microphthalmia-associated transcription factor (MITF) is a master gene regulating differentiation of melanocytes, and a lineage survival oncogene mediating pro-proliferative function in malignant melanoma. However, high expression of MITF also has an anti-proliferative effect. To clarify the therape...

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Veröffentlicht in:	Cancer science 2009-10, Vol.100 (10), p.1863-1869
Hauptverfasser:	Kido, Kenji, Sumimoto, Hidetoshi, Asada, Sakiyo, Okada, Starlyn M, Yaguchi, Tomonori, Kawamura, Naoshi, Miyagishi, Makoto, Saida, Toshiaki, Kawakami, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Melanoma - genetics Melanoma - metabolism Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Signal Transduction - physiology
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