Protumor vs Antitumor Functions of IL-17

Inflammation appears to be a necessity for both metastasis and elimination of tumor cells. IL-17, a proinflammatory cytokine produced by Th17 cells, contributes to both the processes by playing a dual role in the antitumor immunity. On one hand, IL-17 promotes an antitumor cytotoxic T cell response...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-10, Vol.183 (7), p.4169-4175
Hauptverfasser:	Murugaiyan, Gopal, Saha, Bhaskar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Interleukin-17 - biosynthesis Interleukin-17 - physiology Interleukin-17 - secretion Neoplasms - immunology Neoplasms - metabolism Neoplasms - prevention & control T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - secretion
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container_title	The Journal of immunology (1950)
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creator	Murugaiyan, Gopal Saha, Bhaskar
description	Inflammation appears to be a necessity for both metastasis and elimination of tumor cells. IL-17, a proinflammatory cytokine produced by Th17 cells, contributes to both the processes by playing a dual role in the antitumor immunity. On one hand, IL-17 promotes an antitumor cytotoxic T cell response leading to tumor regression. On the other hand, by facilitating angiogenesis and egress of tumor cells from the primary focus, IL-17 promotes tumor growth. Thus, the therapeutic application that uses IL-17 needs to be refined by minimizing its protumor functions.
doi_str_mv	10.4049/jimmunol.0901017
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subjects	Animals Humans Interleukin-17 - biosynthesis Interleukin-17 - physiology Interleukin-17 - secretion Neoplasms - immunology Neoplasms - metabolism Neoplasms - prevention & control T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - secretion
title	Protumor vs Antitumor Functions of IL-17
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