Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor γ-dependent mechanism

Telmisartan is known to block angiotensin (Ang) II type-1 receptors (AT 1R), and also activate peroxisome proliferator-activated receptor γ (PPARγ) signaling. Recently, PPARγ has been implicated as a regulator of cellular proliferation and inflammatory responses. In the present study, we investigate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 2009-10, Vol.464 (3), p.151-155
Hauptverfasser:	Haraguchi, Tamami, Takasaki, Kotaro, Naito, Tetsuya, Hayakawa, Kazuhide, Katsurabayashi, Shutaro, Mishima, Kenichi, Iwasaki, Katsunori, Fujiwara, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Benzimidazoles - pharmacology Benzoates - pharmacology Cerebral Cortex - blood supply Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral ischemia High-mobility group box1 HMGB1 Protein - biosynthesis HMGB1 Protein - blood Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Ischemic Attack, Transient - prevention & control Macrophage/microglia Macrophages - drug effects Macrophages - metabolism Male Mice Microglia - drug effects Microglia - metabolism Neuroprotective Agents - pharmacology PPAR gamma - agonists PPAR gamma - physiology PPARγ Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Telmisartan
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!