Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL

Validation of the bioanalytical method for determination of desloratadine and 3-hydroxydesloratadine was conducted using ultra high pressure liquid chromatography (UPLC) in conjunction with mix mode solid phase extraction. The dynamic range of the assay was from 0.025 ng/mL to 10 ng/mL using 96-well...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2006-02, Vol.40 (3), p.689-706
Hauptverfasser:	Shen, Jim X., Wang, Haiping, Tadros, Samy, Hayes, Roger N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calibration Chromatography, High Pressure Liquid Desloratadine Histamine H1 Antagonists - analysis Histamine H1 Antagonists - blood Humans LC/MS-MS Loratadine - analogs & derivatives Loratadine - analysis Loratadine - blood Mass Spectrometry Mixed-mode SPE Orthogonal Pharmaceutical Solutions - analysis Quantitation Reproducibility of Results UPLC Validation
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