Modulation of PKR activity in cells infected by bovine viral diarrhea virus

Bovine viral diarrhea virus is an important animal pathogen. The cytopathic and noncytopathic biotypes of the virus are associated with distinct pathologic entities. A striking difference between the two biotypes is viral RNA accumulation in infected cells. Viral dsRNA is thought to activate protein...

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Veröffentlicht in:	Virus research 2006-03, Vol.116 (1), p.69-77
Hauptverfasser:	Gil, Laura H.V.G., van Olphen, Alberto L., Mittal, Suresh K., Donis, Ruben O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial Gene Fusion Blotting, Western Bovine viral diarrhea virus Cattle Cell Line Diarrhea Viruses, Bovine Viral - physiology Double stranded RNA-dependent protein kinase eIF-2 Kinase - metabolism Enzyme Activation Eukaryotic Initiation Factor-2 - metabolism Genes, Reporter Innate immunity Luciferases - genetics Models, Biological NF-kappa B - biosynthesis NF-κB Persistent infection Phosphorylation PKR Poliovirus Protein Biosynthesis RNA, Double-Stranded
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