A Preformed Complex of Postsynaptic Proteins Is Involved in Excitatory Synapse Development

Nonsynaptic clusters of postsynaptic proteins have been documented; however, their role remains elusive. We monitored the trafficking of several candidate proteins implicated in synaptogenesis, when nonsynaptic clusters of scaffold proteins are most abundant. We find a protein complex consisting of...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2006-02, Vol.49 (4), p.547-562
Hauptverfasser:	Gerrow, Kimberly, Romorini, Stefano, Nabi, Shahin M., Colicos, Michael A., Sala, Carlo, El-Husseini, Alaa
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - physiology Animals Cell adhesion & migration Cell Adhesion Molecules, Neuronal CELLBIO Cells, Cultured Diagnostic Imaging - methods Disks Large Homolog 4 Protein Dual-Specificity Phosphatases Embryo, Mammalian Green Fluorescent Proteins - metabolism Hippocampus - cytology Immunohistochemistry - methods Intracellular Signaling Peptides and Proteins - physiology Medical research Membrane Proteins - metabolism Membrane Proteins - physiology Models, Neurological MOLNEURO Nerve Tissue Proteins - classification Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Neurons Neurons - cytology Nocodazole - pharmacology Phosphoprotein Phosphatases - physiology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Protein Transport - drug effects PROTEINS Pyridinium Compounds - pharmacokinetics Quaternary Ammonium Compounds - pharmacokinetics Rats Rats, Wistar Recruitment RNA, Small Interfering - pharmacology Signal transduction Synapses - physiology Time Factors Vesicular Glutamate Transport Proteins - metabolism
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