In vitro activation and differentiation of naïve CD4 + and CD8 + T cells into HCV Core- and NS3-specific armed effector cells: A new role for CD4 + T cells

Viral clearance in hepatitis C virus (HCV) infection has been correlated with strong, multi-specific and sustained T cell responses. The number of functionally active effector T cells determines the outcome of infection. Only a small number of antigen-specific naïve T cells are originally present. U...

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