Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines

Oxygen-dependent radiosensitivity of tumour cells reflects direct oxidative damage to DNA, but non-nuclear mechanisms including signalling pathways may also contribute. Mitochondria are likely candidates because not only do they integrate signals from each of the main kinase pathways but mitochondri...

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Veröffentlicht in:	British journal of radiology 2009-10, Vol.82 (982), p.847-854
Hauptverfasser:	ANOOPKUMAR-DUKIE, S, CONERE, T, SISK, G. D, ALLSHIRE, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology bcl-2-Associated X Protein - metabolism Biological and medical sciences Bongkrekic Acid - pharmacology Breast Neoplasms - metabolism Cell Line, Tumor Cyclosporine - pharmacology Female Humans Immunosuppressive Agents - pharmacology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Melanoma - metabolism Mitochondria - drug effects Mitochondria - metabolism Oxidative Stress Radiation Tolerance - drug effects Tacrolimus - pharmacology Uterine Cervical Neoplasms - metabolism
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