Molecular Basis for Phosphorylation-Dependent, PEST-Mediated Protein Turnover

Proteasomal-mediated rapid turnover of proteins is often modulated by phosphorylation of PEST sequences. The E2 protein from papillomavirus participates in gene transcription, DNA replication, and episomal genome maintenance. Phosphorylation of a PEST sequence located in a flexible region accelerate...

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Veröffentlicht in:	Structure (London) 2006-02, Vol.14 (2), p.309-319
Hauptverfasser:	García-Alai, Maria M., Gallo, Mariana, Salame, Marcelo, Wetzler, Diana E., McBride, Alison A., Paci, Maurizio, Cicero, Daniel O., de Prat-Gay, Gonzalo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Circular Dichroism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Models, Molecular Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Papillomavirus Peptides - chemistry Phosphorylation Polyglutamic Acid - chemistry Protein Structure, Secondary Protein Structure, Tertiary Sequence Alignment Viral Proteins - chemistry Viral Proteins - metabolism
Online-Zugang:	Volltext
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