Specific central nervous system recruitment of HLA-G+ regulatory T cells in multiple sclerosis

Objective We have recently described a novel population of natural regulatory T cells (Treg) that are characterized by the expression of HLA‐G and may be found at sites of tissue inflammation (HLA‐Gpos Treg). Here we studied the role of these cells in multiple sclerosis (MS), a prototypic autoimmune...

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Veröffentlicht in:	Annals of neurology 2009-08, Vol.66 (2), p.171-183
Hauptverfasser:	Huang, Yu-Hwa, Zozulya, Alla L., Weidenfeller, Christian, Metz, Imke, Buck, Dorothea, Toyka, Klaus V., Brück, Wolfgang, Wiendl, Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blood-Brain Barrier - pathology Blood-Brain Barrier - physiopathology Brain - immunology Brain - pathology Brain - physiopathology Cell Line Cell Movement Female Flow Cytometry Histocompatibility Antigens Class I - metabolism HLA Antigens - metabolism HLA-G Antigens Humans Immunohistochemistry Male Medical sciences Middle Aged Multiple Sclerosis - immunology Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Receptors, Antigen, T-Cell - metabolism Receptors, CCR5 - metabolism Receptors, Cytokine - metabolism T-Lymphocytes, Regulatory - physiology Young Adult
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