Possible Involvement of Chemokine-induced Platelet Activation in Thrombophilic Diathesis of Antiphospholipid Syndrome

Among the heterogeneous antiphospholipid antibodies, many studies suggest that those directed to β2‐glycoprotein I (β2GPI) are the major pathogenic antibodies in antiphospholipid syndrome (APS). They have been shown to activate the coagulation pathway via several mechanisms, activate platelets via t...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-09, Vol.1173 (1), p.137-145
Hauptverfasser:	Kubota, Tetsuo, Fukuya, Yasuko, Hashimoto, Rieko, Kanda, Takashi, Suzuki, Hidenori, Okamura, Yosuke, Nanki, Toshihiro, Miyasaka, Nobuyuki, Umezawa, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation anti-β2-glycoprotein I antibodies Antibodies antiphospholipid syndrome Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - immunology Autoantibodies - pharmacology Benzamides - pharmacology beta 2-Glycoprotein I - immunology Blood Platelets - drug effects Blood Platelets - metabolism Cell Line Cells, Cultured Chemokine CCL5 - genetics Chemokine CCL5 - metabolism Chemokine CCL5 - pharmacology Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Chemokine CX3CL1 - pharmacology chemokines Chemokines - genetics Chemokines - metabolism Chemokines - pharmacology Coagulation Collagens Cyclohexanones - pharmacology Disease Susceptibility Endothelial cells Enzyme-Linked Immunosorbent Assay Gene Expression - drug effects Humans Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism NF-κB inhibitor Pathways Platelet Activation - drug effects platelet adhesion platelet aggregation Platelet Aggregation - drug effects Platelets Reverse Transcriptase Polymerase Chain Reaction Thrombin Thromboplastin - genetics Thromboplastin - metabolism Thrombosis - immunology Thrombosis - metabolism
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