HE3286: A Novel Synthetic Steroid as an Oral Treatment for Autoimmune Disease

HE3286 (17α‐ethynyl‐5‐androstene‐3β, 7β, 17β‐triol) is a synthetic derivative of a natural anti‐inflammatory steroid, β‐AET (5‐androstene‐3β, 7β, 17β‐triol). HE3286 is orally bioavailable and treats established disease in models of ulcerative colitis, collagen‐induced arthritis, and collagen antibod...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-09, Vol.1173 (1), p.781-790
Hauptverfasser:	Ahlem, C., Auci, D., Mangano, K., Reading, C., Frincke, J., Stickney, D., Nicoletti, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral androstenetriol Androstenols - administration & dosage Androstenols - therapeutic use Animals Arthritis Autoimmune diseases Autoimmune Diseases - drug therapy Clinical Trials as Topic Colitis, Ulcerative - drug therapy Collagens Dehydroepiandrosterone - administration & dosage Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - therapeutic use Derivatives DHEA Dose-Response Relationship, Drug Drug Evaluation, Preclinical Encephalomyelitis, Autoimmune, Experimental - drug therapy Estradiol - administration & dosage Estradiol - analogs & derivatives Estradiol - therapeutic use Estrogen Antagonists - administration & dosage Estrogen Antagonists - therapeutic use Female Hormones Humans Male Medical services Mice Mice, Inbred Strains multiple sclerosis Rats Rats, Wistar Receptors Steroids Treatment Outcome ulcerative colitis
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