Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease
The inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are illness characterized by a chronic clinical course of relapse and remission associated with self‐destructive inflammation of the gastrointestinal tract. In both UC and CD, leukocyte infiltration i...
Gespeichert in:
| Veröffentlicht in: | Annals of the New York Academy of Sciences 2009-09, Vol.1173 (1), p.350-356 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 356 |
|---|---|
| container_issue | 1 |
| container_start_page | 350 |
| container_title | Annals of the New York Academy of Sciences |
| container_volume | 1173 |
| creator | Nishimura, Miyuki Kuboi, Yoshikazu Muramoto, Kenzo Kawano, Tetsu Imai, Toshio |
| description | The inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are illness characterized by a chronic clinical course of relapse and remission associated with self‐destructive inflammation of the gastrointestinal tract. In both UC and CD, leukocyte infiltration into the intestine is fundamental event in disease development and progression where the chemokines and their receptors are orchestrating the tissue‐specific and the cell type–selective trafficking of leukocytes. In this review, we will discuss the homeostatic and inflammatory roles of the chemokines and their receptors with their potentials and promise as molecular targets for therapeutic interventions in human IBD, focusing on the recently identified role of the CX3CL1–CX3CR1 axis, as well as the CCL20–CCR6, CCL25–CCR9, and CXCL10–CXCR3 pathways. |
| doi_str_mv | 10.1111/j.1749-6632.2009.04738.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67654035</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67654035</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6258-5c8b28be3f9fc0862f74ff3cc40cab4f37ab7d56f004c1a4b6ff7f101b7309353</originalsourceid><addsrcrecordid>eNqNkU9v0zAcQC0EYmXwFVBOiEvCz__tC9Lo6DaYigQFxMlyPJulS5pip6z99ji0Gjc2X2zJz8-WH0IFhgrn8WZZYcl0KQQlFQHQFTBJVbV9hCZ3G4_RBEDKUmlCj9CzlJYAmCgmn6IjrCVXWJIJmk2vfdffNCufCpuKef_bt8Xi2ke79puhccXCxp9-SEXoY3GxCq3tOjv0cVe8628zetokb5N_jp4E2yb_4jAfo6-z94vpeXn56exienJZOkG4KrlTNVG1p0EHB0qQIFkI1DkGztYsUGlrecVFAGAOW1aLEGTAgGtJQVNOj9GrvXcd-18bnwbTNcn5trUr32-SEVJwBg8AKVNca0ruBQkoyoQcwdf_BbHKj85Swe5HpQKOGdc4o2qPutinFH0w69h0Nu4MBjO2NkszJjVjUjO2Nn9bm20--vJwy6bu_NW_g4e4GXi7B26b1u8eLDbzHydfxmUWlHtBkwa_vRPYeJM_mkpuvs_PjP48-7aYfjw3H-gfxobF9A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780514591</pqid></control><display><type>article</type><title>Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Nishimura, Miyuki ; Kuboi, Yoshikazu ; Muramoto, Kenzo ; Kawano, Tetsu ; Imai, Toshio</creator><creatorcontrib>Nishimura, Miyuki ; Kuboi, Yoshikazu ; Muramoto, Kenzo ; Kawano, Tetsu ; Imai, Toshio</creatorcontrib><description>The inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are illness characterized by a chronic clinical course of relapse and remission associated with self‐destructive inflammation of the gastrointestinal tract. In both UC and CD, leukocyte infiltration into the intestine is fundamental event in disease development and progression where the chemokines and their receptors are orchestrating the tissue‐specific and the cell type–selective trafficking of leukocytes. In this review, we will discuss the homeostatic and inflammatory roles of the chemokines and their receptors with their potentials and promise as molecular targets for therapeutic interventions in human IBD, focusing on the recently identified role of the CX3CL1–CX3CR1 axis, as well as the CCL20–CCR6, CCL25–CCR9, and CXCL10–CXCR3 pathways.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.2009.04738.x</identifier><identifier>PMID: 19758172</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Chemokine CCL20 - metabolism ; Chemokine CX3CL1 - metabolism ; chemokine receptors ; chemokines ; Chemokines, CC - metabolism ; Crohn's Disease ; Human ; Humans ; Illnesses ; Infiltration ; inflammatory bowel disease ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory Bowel Diseases - metabolism ; Inflammatory Bowel Diseases - physiopathology ; Intestines ; Leukocytes ; Models, Biological ; Progressions ; Receptors ; Receptors, CCR - metabolism ; Receptors, CCR6 - metabolism ; Signal Transduction - drug effects ; Signal Transduction - physiology ; ulcerative colitis</subject><ispartof>Annals of the New York Academy of Sciences, 2009-09, Vol.1173 (1), p.350-356</ispartof><rights>2009 New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6258-5c8b28be3f9fc0862f74ff3cc40cab4f37ab7d56f004c1a4b6ff7f101b7309353</citedby><cites>FETCH-LOGICAL-c6258-5c8b28be3f9fc0862f74ff3cc40cab4f37ab7d56f004c1a4b6ff7f101b7309353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.2009.04738.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.2009.04738.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19758172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishimura, Miyuki</creatorcontrib><creatorcontrib>Kuboi, Yoshikazu</creatorcontrib><creatorcontrib>Muramoto, Kenzo</creatorcontrib><creatorcontrib>Kawano, Tetsu</creatorcontrib><creatorcontrib>Imai, Toshio</creatorcontrib><title>Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>The inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are illness characterized by a chronic clinical course of relapse and remission associated with self‐destructive inflammation of the gastrointestinal tract. In both UC and CD, leukocyte infiltration into the intestine is fundamental event in disease development and progression where the chemokines and their receptors are orchestrating the tissue‐specific and the cell type–selective trafficking of leukocytes. In this review, we will discuss the homeostatic and inflammatory roles of the chemokines and their receptors with their potentials and promise as molecular targets for therapeutic interventions in human IBD, focusing on the recently identified role of the CX3CL1–CX3CR1 axis, as well as the CCL20–CCR6, CCL25–CCR9, and CXCL10–CXCR3 pathways.</description><subject>Chemokine CCL20 - metabolism</subject><subject>Chemokine CX3CL1 - metabolism</subject><subject>chemokine receptors</subject><subject>chemokines</subject><subject>Chemokines, CC - metabolism</subject><subject>Crohn's Disease</subject><subject>Human</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infiltration</subject><subject>inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - drug therapy</subject><subject>Inflammatory Bowel Diseases - metabolism</subject><subject>Inflammatory Bowel Diseases - physiopathology</subject><subject>Intestines</subject><subject>Leukocytes</subject><subject>Models, Biological</subject><subject>Progressions</subject><subject>Receptors</subject><subject>Receptors, CCR - metabolism</subject><subject>Receptors, CCR6 - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>ulcerative colitis</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v0zAcQC0EYmXwFVBOiEvCz__tC9Lo6DaYigQFxMlyPJulS5pip6z99ji0Gjc2X2zJz8-WH0IFhgrn8WZZYcl0KQQlFQHQFTBJVbV9hCZ3G4_RBEDKUmlCj9CzlJYAmCgmn6IjrCVXWJIJmk2vfdffNCufCpuKef_bt8Xi2ke79puhccXCxp9-SEXoY3GxCq3tOjv0cVe8628zetokb5N_jp4E2yb_4jAfo6-z94vpeXn56exienJZOkG4KrlTNVG1p0EHB0qQIFkI1DkGztYsUGlrecVFAGAOW1aLEGTAgGtJQVNOj9GrvXcd-18bnwbTNcn5trUr32-SEVJwBg8AKVNca0ruBQkoyoQcwdf_BbHKj85Swe5HpQKOGdc4o2qPutinFH0w69h0Nu4MBjO2NkszJjVjUjO2Nn9bm20--vJwy6bu_NW_g4e4GXi7B26b1u8eLDbzHydfxmUWlHtBkwa_vRPYeJM_mkpuvs_PjP48-7aYfjw3H-gfxobF9A</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Nishimura, Miyuki</creator><creator>Kuboi, Yoshikazu</creator><creator>Muramoto, Kenzo</creator><creator>Kawano, Tetsu</creator><creator>Imai, Toshio</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>SOI</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease</title><author>Nishimura, Miyuki ; Kuboi, Yoshikazu ; Muramoto, Kenzo ; Kawano, Tetsu ; Imai, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6258-5c8b28be3f9fc0862f74ff3cc40cab4f37ab7d56f004c1a4b6ff7f101b7309353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Chemokine CCL20 - metabolism</topic><topic>Chemokine CX3CL1 - metabolism</topic><topic>chemokine receptors</topic><topic>chemokines</topic><topic>Chemokines, CC - metabolism</topic><topic>Crohn's Disease</topic><topic>Human</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Infiltration</topic><topic>inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases - drug therapy</topic><topic>Inflammatory Bowel Diseases - metabolism</topic><topic>Inflammatory Bowel Diseases - physiopathology</topic><topic>Intestines</topic><topic>Leukocytes</topic><topic>Models, Biological</topic><topic>Progressions</topic><topic>Receptors</topic><topic>Receptors, CCR - metabolism</topic><topic>Receptors, CCR6 - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><topic>ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishimura, Miyuki</creatorcontrib><creatorcontrib>Kuboi, Yoshikazu</creatorcontrib><creatorcontrib>Muramoto, Kenzo</creatorcontrib><creatorcontrib>Kawano, Tetsu</creatorcontrib><creatorcontrib>Imai, Toshio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishimura, Miyuki</au><au>Kuboi, Yoshikazu</au><au>Muramoto, Kenzo</au><au>Kawano, Tetsu</au><au>Imai, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2009-09</date><risdate>2009</risdate><volume>1173</volume><issue>1</issue><spage>350</spage><epage>356</epage><pages>350-356</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>The inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are illness characterized by a chronic clinical course of relapse and remission associated with self‐destructive inflammation of the gastrointestinal tract. In both UC and CD, leukocyte infiltration into the intestine is fundamental event in disease development and progression where the chemokines and their receptors are orchestrating the tissue‐specific and the cell type–selective trafficking of leukocytes. In this review, we will discuss the homeostatic and inflammatory roles of the chemokines and their receptors with their potentials and promise as molecular targets for therapeutic interventions in human IBD, focusing on the recently identified role of the CX3CL1–CX3CR1 axis, as well as the CCL20–CCR6, CCL25–CCR9, and CXCL10–CXCR3 pathways.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19758172</pmid><doi>10.1111/j.1749-6632.2009.04738.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2009-09, Vol.1173 (1), p.350-356 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67654035 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Chemokine CCL20 - metabolism Chemokine CX3CL1 - metabolism chemokine receptors chemokines Chemokines, CC - metabolism Crohn's Disease Human Humans Illnesses Infiltration inflammatory bowel disease Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - physiopathology Intestines Leukocytes Models, Biological Progressions Receptors Receptors, CCR - metabolism Receptors, CCR6 - metabolism Signal Transduction - drug effects Signal Transduction - physiology ulcerative colitis |
| title | Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T11%3A53%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemokines%20as%20Novel%20Therapeutic%20Targets%20for%20Inflammatory%20Bowel%20Disease&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=Nishimura,%20Miyuki&rft.date=2009-09&rft.volume=1173&rft.issue=1&rft.spage=350&rft.epage=356&rft.pages=350-356&rft.issn=0077-8923&rft.eissn=1749-6632&rft_id=info:doi/10.1111/j.1749-6632.2009.04738.x&rft_dat=%3Cproquest_cross%3E67654035%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780514591&rft_id=info:pmid/19758172&rfr_iscdi=true |